Results 91 to 100 of about 2,487,806 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Synchronization in random networks with given expected degree sequences [PDF]

open access: yes, 2008
Synchronization in random networks with given expected degree sequences is studied. We also investigate in details the synchronization in networks whose topology is described by classical random graphs, power-law random graphs and hybrid graphs when N ...
Kocarev, L., Checco, P., Biey, Mario
core  

Thresholds and the structure of sparse random graphs [PDF]

open access: yes, 2003
In this thesis, we obtain approximations to the non-3-colourability threshold of sparse random graphs and we investigate the structure of random graphs near the region where the transition from 3-colourability to non-3-colourability seems to occur.
Fountoulakis, N., Fountoulakis, N
core   +1 more source

A Comprehensive Approach to Synthetic Distribution Grid Generation: Erdős–Rényi to Barabási-Albert [PDF]

open access: yesAUT Journal of Electrical Engineering
In this extended study, the focus is on advancing the generation of synthetic distribution grids (SDGs) through the introduction of a new algorithm based on the Barabási-Albert random graph model.
Mohammad Shahraeini
doaj   +1 more source

Performance Enhancements for Asynchronous Random Access Protocols over Satellite [PDF]

open access: yes, 2011
In this paper, a novel enhancement of the well known ALOHA random access mechanism is presented which largely extends the achievable throughput compared to traditional ALOHA and provides significantly lower packet loss rates. The novel mechanism, called
Kissling, Christian, Christian Kissling
core   +1 more source

Exponential random graph models: examples and phase transitions

open access: yes, 2022
reservedIn this thesis we will analyze some examples of exponential random graph models: we will determine, when possible, the exact formula for the probability associated to the random graph ensemble and then we will discuss a model that exhibits phase ...
VIANELLO, LINDA
core  

Critical random graphs : limiting constructions and distributional properties [PDF]

open access: yes, 2010
We consider the Erdos-Renyi random graph G(n, p) inside the critical window, where p = 1/n + lambda n(-4/3) for some lambda is an element of R. We proved in Addario-Berry et al.
Goldschmidt, C. (Christina)   +6 more
core  

Limiting behaviour of random spatial graphs and asymptotically homogeneous RWRE [PDF]

open access: yes, 2005
We consider several random spatial graphs of the nearest-neighbour type, including the k- nearest neighbours graph, the on-line nearest-neighbour graph, and the minimal directed spanning tree.
Wade, Andrew R   +2 more
core  

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