Results 71 to 80 of about 2,487,806 (297)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Random triangles in random graphs
Random Structures & Algorithms, 2021 AbstractIn a recent paper, Oliver Riordan shows that for and p up to and slightly larger than the threshold for a Kr‐factor, the hypergraph formed by the copies of Kr in G(n, p) contains a copy of the binomial random hypergraph with . For r = 3, he gives a slightly weaker result where the density in the random hypergraph is reduced by a constant ...
openaire +3 more sources
Numerical evidence for phase transitions of NP-complete problems for instances drawn from Lévy-stable distributions [PDF]
, 2012 Random NP-Complete problems have come under study as an important tool used in the analysis of optimization algorithms and help in our understanding of how to properly address issues of computational intractability.
Connelly, Abram
core +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Network Motifs: Mean and Variance for the Count
Revstat Statistical Journal, 2006 Network motifs are at the core of modern studies on biological networks, trying to encompass global features such as small-world or scale-free properties. Detection of significant motifs may be based on two different approaches: either a comparison with
C. Matias +4 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Directed random geometric graphs: structural and spectral properties
Journal of Physics: Complexity, 2022 In this work we analyze structural and spectral properties of a model of directed random geometric graphs: given n vertices uniformly and independently distributed on the unit square, a directed edge is set between two vertices if their distance is ...
Kevin Peralta-Martinez +1 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
On social networks and collaborative recommendation [PDF]
, 2009 Social network systems, like last.fm, play a significant role in Web 2.0, containing large amounts of multimedia-enriched data that are enhanced both by explicit user-provided annotations and implicit aggregated feedback describing the personal ...
Stathopoulos, Vassilios +8 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source