Results 61 to 70 of about 2,603,262 (299)
Hamiltonicity of graphs perturbed by a random geometric graph [PDF]
, 2022 We study Hamiltonicity in graphs obtained as the union of a deterministic $n$-vertex graph $H$ with linear degrees and a $d$-dimensional random geometric graph $G^d(n,r)$, for any $d\geq1$. We obtain an asymptotically optimal bound on the minimum $r$ for
Alberto Espuny Díaz +2 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Random triangles in random graphs
Random Structures & Algorithms, 2021 AbstractIn a recent paper, Oliver Riordan shows that for and p up to and slightly larger than the threshold for a Kr‐factor, the hypergraph formed by the copies of Kr in G(n, p) contains a copy of the binomial random hypergraph with . For r = 3, he gives a slightly weaker result where the density in the random hypergraph is reduced by a constant ...
openaire +3 more sources
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Directed random geometric graphs: structural and spectral properties
Journal of Physics: Complexity, 2022 In this work we analyze structural and spectral properties of a model of directed random geometric graphs: given n vertices uniformly and independently distributed on the unit square, a directed edge is set between two vertices if their distance is ...
Kevin Peralta-Martinez +1 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Synchronization in random networks with given expected degree sequences [PDF]
, 2008 Synchronization in random networks with given expected degree sequences is studied. We also investigate in details the synchronization in networks whose topology is described by classical random graphs, power-law random graphs and hybrid graphs when N ...
Kocarev, L., Checco, P., Biey, Mario
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 1997 Revised chapter for new edition of book "The Mathematics of Paul Erd\H{o}s"
openaire +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source