Results 71 to 80 of about 180,895 (263)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Inclusive random sampling in graphs and networks
Applied Network Science, 2023 It is often of interest to sample vertices from a graph with a bias towards higher-degree vertices. One well-known method, which we call random neighbor or RN, involves taking a vertex at random and exchanging it for one of its neighbors.
Yitzchak Novick, Amotz Bar-Noy
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
hergm: Hierarchical Exponential-Family Random Graph Models
Journal of Statistical Software, 2018 We describe the R package hergm that implements hierarchical exponential-family random graph models with local dependence. Hierarchical exponential-family random graph models with local dependence tend to be superior to conventional exponential-family ...
Michael Schweinberger, Pamela Luna
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Toppling numbers of complete and random graphs [PDF]
Discrete Mathematics & Theoretical Computer Science, 2014 Graph ...
Anthony Bonato +2 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Random independent sets in triangle-free graphs
Forum of Mathematics, SigmaWe establish several new results on the existence of probability distributions on the independent sets in triangle-free graphs where each vertex is present with a given probability.
Anders Martinsson, Raphael Steiner
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