Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
On linear codes with random multiplier vectors and the maximum trace dimension property
Let CC be a linear code of length nn and dimension kk over the finite field Fqm{{\mathbb{F}}}_{{q}^{m}}. The trace code Tr(C){\rm{Tr}}\left(C) is a linear code of the same length nn over the subfield Fq{{\mathbb{F}}}_{q}.
Erdélyi Márton +3 more
doaj +1 more source
Correlation test for code sequence randomness with almost linear computational complexity
Background. The purpose of this article is to create and study a new test of random code sequence quality with low computational complexity. Materials and methods.
V.I. Volchikhin +3 more
doaj +1 more source
Steel Catenary Riser-Seabed Interaction Due to Caspian Sea Environmental Conditions [PDF]
This paper investigates the integrated riser/vessel system which is subjected to random waves. Riser pipelines are the main components of the oil and gas offshore platforms.
Abdolrahim Taheri, Reza Siahtiri
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Combinatorial NLTS From the Overlap Gap Property [PDF]
In an important recent development, Anshu, Breuckmann, and Nirkhe \cite{anshu2022nlts} resolved positively the so-called No Low-Energy Trivial State (NLTS) conjecture by Freedman and Hastings.
Eric R. Anschuetz +2 more
doaj +1 more source
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Analyzing time-to-first-spike coding schemes: A theoretical approach
Spiking neural networks (SNNs) using time-to-first-spike (TTFS) codes, in which neurons fire at most once, are appealing for rapid and low power processing.
Lina Bonilla +4 more
doaj +1 more source
Secure and Private Cloud Storage Systems with Random Linear Fountain Codes
An information theoretic approach to security and privacy called Secure And Private Information Retrieval (SAPIR) is introduced. SAPIR is applied to distributed data storage systems. In this approach, random combinations of all contents are stored across
Kiskani, Mohsen Karimzadeh +1 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source

