Results 71 to 80 of about 138,052 (292)

Minimal and random generation of permutation and matrix groups

, 2012
We prove explicit bounds on the numbers of elements needed to generate various types of finite permutation groups and finite completely reducible matrix groups, and present examples to show that they are sharp in all cases.
Derek F. Holt, Holt, Derek, Roney-Dougal, Colva M., Colva M. Roney-dougal, Holt, Derek F., Roney-Dougal, Colva Mary   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Universal shocks in random matrix theory [PDF]

Physical Review E, 2010
We link the appearance of universal kernels in random matrix ensembles to the phenomenon of shock formation in some fluid dynamical equations. Such equations are derived from Dyson's random walks after a proper rescaling of the time. In the case of the Gaussian Unitary Ensemble, on which we focus in this letter, we show that the orthogonal polynomials,
Blaizot, Jean-Paul, Nowak, Maciej A.
openaire   +3 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Ensemble averaging in JT gravity from entanglement in Matrix Quantum Mechanics

Journal of High Energy Physics, 2023
We consider the generalization of a matrix integral with arbitrary spectral curve ρ 0(E) to a 0+1D theory of matrix quantum mechanics (MQM). Using recent techniques for 1D quantum systems at large-N, we formulate a hydrodynamical effective theory for the
Gabriele Di Ubaldo, Giuseppe Policastro
doaj   +1 more source

PDE Methods in Random Matrix Theory [PDF]

, 2020
This article begins with a brief review of random matrix theory, followed by a discussion of how the large-$N$ limit of random matrix models can be realized using operator algebras. I then explain the notion of "Brown measure," which play the role of the eigenvalue distribution for operators in an operator algebra.
openaire   +2 more sources

Random matrix theory and quantum chromodynamics [PDF]

, 2017
Abstract This chapter was originally presented to a mixed audience of physicists and mathematicians with some basic working knowledge of random matrix theory. The first part is devoted to the solution of the chiral Gaussian unitary ensemble in the presence of characteristic polynomials, using orthogonal polynomial techniques.
Akemann, Gernot, Schehr, Grégory, Altland, Alexander, Fyodorov, Yan V., O'Connell,, Neil, Cugliandolo, Leticia F.   +5 more
openaire   +3 more sources

Singular random matrix decompositions: Jacobians. [PDF]

, 2002
For a singular random matrix Y, we find the Jacobians associated with the following decompositions; QR, Polar, Singular Value (SVD), L'U, L'DM and modified QR (QDR).
González Farías, Graciela, Díaz García, José A.   +1 more
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source