Results 51 to 60 of about 2,028,751 (264)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Fully passive quantum random number generation with untrusted light [PDF]

APL Quantum
Quantum random number generators (QRNGs) harness the inherent unpredictability of quantum mechanics to produce true randomness. Yet, in many optical implementations, the light source remains a potential vulnerability—susceptible to deviations from ideal ...
KaiWei Qiu, Yu Cai, Nelly H. Y. Ng, Jing Yan Haw   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Optimal algorithms for universal random number generation from finite memory sources

, 2014
We study random number generators (RNGs), both in the fixed to variable-length (FVR) and the variable to fixed-length (VFR) regimes, in a universal setting in which the input is a finite memory source of arbitrary order and unknown parameters, with ...
Seroussi, Gadiel, Weinberger, Marcelo J.
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Recommendations and illustrations for the evaluation of photonic random number generators

, 2017
The never-ending quest to improve the security of digital information combined with recent improvements in hardware technology has caused the field of random number generation to undergo a fundamental shift from relying solely on pseudo-random algorithms
Baumgartner, Gerald B., Hart, Joseph D., Murphy, Thomas E., Roy, Rajarshi, Terashima, Yuta, Uchida, Atsushi   +5 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Quantum random number generation for 1.25 GHz quantum key distribution systems

, 2015
Security proofs of quantum key distribution (QKD) systems usually assume that the users have access to source of perfect randomness. State-of-the-art QKD systems run at frequencies in the GHz range, requiring a sustained GHz rate of generation and ...
Houlmann, R., Lim, C. C. W., Martin, A., Sanguinetti, B., Zbinden, H.   +4 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

On parallel random number generation for accelerating simulations of communication systems [PDF]

Advances in Radio Science, 2014
Powerful compute clusters and multi-core systems have become widely available in research and industry nowadays. This boost in utilizable computational power tempts people to run compute-intensive tasks on those clusters, either for speed or accuracy ...
C. Brugger, S. Weithoffer, C. de Schryver, U. Wasenmüller, N. Wehn   +4 more
doaj   +1 more source