Results 101 to 110 of about 77,348 (299)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
SLOPPGEN: A Problem Generator for the Two-Dimensional Rectangular Single Large Object Placement Problem With a Single Defect [PDF]
In this paper, a problem generator for the Two-Dimensional Rectangular Single Large Object Placement Problem is presented. The parameters defining this problem are identified and described.
Vera Neidlein, Gerhard Wäscher
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
SOURCES OF RANDOMNESS FOR USE IN RANDOM NUMBER GENERATION
International Journal of Computing, 2014 Efficient generation of random numbers plays significant role in cryptographic applications. Such a generator has to produce unpredictable and un-correlated random bits. Random number generators are classified as pseudo-random number generators (PRNGs) and true random number generators (TRNGs).
Anastasios Fragopoulos +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Application of optimization algorithms in the design of a superconducting A.C. generator rotor [PDF]
, 1990 The superconducting a.c. generator is expected to be the optimum choice among a.c. generation systems in future because of its reduced size, high efficiency, high terminal voltage and its contribution to the stability of the power system.
Safi, Sabah K.
core
Random Walks Arising in Random Number Generation
The Annals of Probability, 1987 Random number generators often work by recursively computing \(X_{n+1}\equiv aX_ n+b(mod p)\). Various schemes exist for combining these random number generators. In one scheme, a and b are themselves chosen each time from another generator. Assuming that this second source is truly random, we investigate how long it takes for \(X_ n\) to become random.
Chung, F. R. K. +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
An ultra-low power CMOS random number generator
, 2008 This paper proposes an ultra-low power CMOS random number generator (RING), which is based on an oscillator-sampling architecture. The noisy oscillator consists of a dual-drain MOS transistor, a noise generator and a voltage control oscillator.
Zhang, W +3 more
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source