Results 51 to 60 of about 31,009 (261)
PPanGGOLiN: Depicting microbial diversity via a partitioned pangenome graph.
PLoS Computational Biology, 2020 The use of comparative genomics for functional, evolutionary, and epidemiological studies requires methods to classify gene families in terms of occurrence in a given species.
Guillaume Gautreau +13 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Randomized Spatial Partition for Scene Recognition [PDF]
, 2012 The spatial layout of images plays a critical role in natural scene analysis. Despite previous work, e.g., spatial pyramid matching, how to design optimal spatial layout for scene classification remains an open problem due to the large variations of scene categories.
Yuning Jiang 0001 +2 more
openaire +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Machine-learning certification of multipartite entanglement for noisy quantum hardware
New Journal of PhysicsEntanglement is a fundamental aspect of quantum physics, both conceptually and for its many applications. Classifying an arbitrary multipartite state as entangled or separable—a task referred to as the separability problem—poses a significant challenge ...
Andreas J C Fuchs +7 more
doaj +1 more source
Partitioning Random Graphs into Monochromatic Components
The Electronic Journal of Combinatorics, 2017 Erdős, Gyárfás, and Pyber (1991) conjectured that every $r$-colored complete graph can be partitioned into at most $r-1$ monochromatic components; this is a strengthening of a conjecture of Lovász (1975) and Ryser (1970) in which the components are only required to form a cover.
Deepak Bal, Louis DeBiasio
openaire +3 more sources
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
The Mean and the Variance as Dual Concepts in a Fundamental Duality
AxiomsA basic duality arises throughout the mathematical and natural sciences. Traditionally, logic is thought to be based on the Boolean logic of subsets, but the development of category theory in the mid-twentieth century shows the duality between subsets ...
David Ellerman
doaj +1 more source