Results 91 to 100 of about 4,929,720 (302)

Impact of simplified methods of growth recording on genetic parameter estimates of Tunisian local goat population under a low input production system

open access: yesItalian Journal of Animal Science, 2020
The study aims to simulate the alternative methods of simplifying weight recording of Tunisian local kids and assesses the impact of their use from a genetic point of view to set up the basis for the future improvement of this important component of ...
A. Atoui   +3 more
doaj   +1 more source

Linear regression with random projections.

open access: yesJ. Mach. Learn. Res., 2012
We investigate a method for regression that makes use of a randomly generated subspace $G_P$ (of finite dimension $P$) of a given large (possibly infinite) dimensional function space $F$, for example, $L_{2}([0,1]^d)$. $G_P$ is defined as the span of $P$ random features that are linear combinations of a basis functions of $F$ weighted by random ...
Maillard, Odalric, Munos, Rémi
openaire   +2 more sources

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Random coefficient regressions: parametric goodness of fit tests [PDF]

open access: yes, 1995
Random coefficient regression models have been applied in different fields during recent years and they are a unifying frame for many statistical models.
Delicado, Pedro, Romo, Juan
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Genetic effects of season on the preweaning growth of beef cattle: a first approach to Retinta calves

open access: yesRevista Colombiana de Ciencias Pecuarias, 2019
Background: Heat stress derived from global warming is causing major economic losses in the livestock industry. Objective: To develop a novel methodological approach for determining the influence of climatic factors on the estimation of genetic ...
Rosa M. Morales   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Use of gene expression data for predicting continuous phenotypes for animal production and breeding

open access: yesAnimal, 2008
Traits such as disease resistance are costly to evaluate and slow to improve using current methods. Analysis of gene expression profiles (e.g. DNA microarrays) has potential for predicting such phenotypes and has been used in an analogous way to classify
N. Robinson, M. Goddard, B. Hayes
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

open access: yesMolecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David   +12 more
wiley   +1 more source

Genetic parameters of a random regression model for daily feed intake of performance tested French Landrace and Large White growing pigs

open access: yesGenetics Selection Evolution, 2001
Daily feed intake data of 1 279 French Landrace (FL, 1 039 boars and 240 castrates) and 2 417 Large White (LW, 2 032 boars and 385 castrates) growing pigs were recorded with electronic feed dispensers in three French central testing stations from 1992 ...
Hofer Andreas   +3 more
doaj   +1 more source

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