Results 81 to 90 of about 2,173,075 (279)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

The genetic analysis of tolerance to infections: A review

open access: yesFrontiers in Genetics, 2012
Tolerance to infections is defined as the ability of a host to limit the impact of a given pathogen burden on host performance. Uncoupling resistance and tolerance is a challenge, and there is a need to be able to separate them using specific trait ...
Antti eKause, Jørgen eØdegård
doaj   +1 more source

Truncated Stochastic Approximation with Moving Bounds: Convergence [PDF]

open access: yes, 2011
In this paper we propose a wide class of truncated stochastic approximation procedures with moving random bounds. While we believe that the proposed class of procedures will find its way to a wider range of applications, the main motivation is to ...
Sharia, Teo
core   +1 more source

Stein Random Feature Regression

open access: yes
In large-scale regression problems, random Fourier features (RFFs) have significantly enhanced the computational scalability and flexibility of Gaussian processes (GPs) by defining kernels through their spectral density, from which a finite set of Monte Carlo samples can be used to form an approximate low-rank GP.
Warren, Houston   +2 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Use of Repeated Group Measurements with Drop Out Animals for Variance Component Estimation and Genetic Evaluation: A Simulation Study

open access: yesG3: Genes, Genomes, Genetics, 2019
The efficiency of feed utilization plays an important role in animal breeding. However, measuring feed intake (FI) is costly on an individual basis under practical conditions.
Hongding Gao   +7 more
doaj   +1 more source

Variable selection in multiple regression with random design

open access: yes, 2015
We propose a method for variable selection in multiple regression with random predictors. This method is based on a criterion that permits to reduce the variable selection problem to a problem of estimating suitable permutation and dimensionality.
Mbina, Alban Mbina   +2 more
core  

Fixed and random covariance regression analyses

open access: yesThe Annals of Statistics
25 ...
Zou, Tao   +3 more
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Random Forest Regression May Become the Optimal Regression Model for Osteoarthritis of the Knee in Elderly, in the Context of Embodied Cognition and Psychosomatic Medicine

open access: yesJournal of Multidisciplinary Healthcare
Guangyuan Ma,1,* Junjie Chen,2,3,* Jingchi Li,2,3 Hui Shi,1 Yi Chen1 1School of Humanities and Management, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Department of Orthopedics, The Affiliated Traditional ...
Ma G, Chen J, Li J, Shi H, Chen Y
doaj  

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