Results 61 to 70 of about 4,929,720 (302)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Modeling daily yields of milk, fat, protein, and lactose of New Zealand dairy goats undergoing standard and extended lactations

Journal of Dairy Science
: This study aimed to assess the milk production data for New Zealand dairy goats in either a standard lactation (SL; ≤305 d in milk [DIM]) or extended lactation (EL; >305 and ≤670 DIM) using a random regression (RR) with third- and fifth-order Legendre ...
M. Boshoff, N. Lopez-Villalobos, C. Andrews, S-A. Turner   +3 more
doaj   +1 more source

Hierarchical Bayesian models for genotype × environment estimates in post-weaning gain of Hereford bovine via reaction norms Modelos hierárquicos bayesianos para estimativas de interação genótipo × ambiente em ganho pós-desmama de bovinos Hereford via normas de reação

Revista Brasileira de Zootecnia, 2011
It was evaluated statistical models with different assumptions to define the one that best describes the presence of genotype × environment interaction on adjusted post-weaning weight gain (PWG345) of Hereford cattle, through the study of reactions norms
Leandro Lunardini Cardoso, José Braccini Neto, Fernando Flores Cardoso, Jaime Araújo Cobuci, Igor de Oliveira Biassus, Júlio Otávio Jardim Barcellos   +5 more
doaj   +1 more source

Risk Bounds for Random Regression Graphs [PDF]

Foundations of Computational Mathematics, 2007
We consider the regression problem and describe an algorithm approximating the regression function by estimators piecewise constant on the elements of an adaptive partition. The partitions are iteratively constructed by suitable random merges and splits, using cuts of arbitrary geometry.
Andrea Caponnetto, Steve Smale
openaire   +1 more source

Locally Adaptive Function Estimation for Binary Regression Models [PDF]

, 2003
In this paper we present a nonparametric Bayesian approach for fitting unsmooth or highly oscillating functions in regression models with binary responses. The approach extends previous work by Lang et al. (2002) for Gaussian responses.
Jerak, A., Jerak, Alexander, Lang, S., Lang, Stefan   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Estimativas de parâmetros genéticos para produção de leite e persistência da lactação em vacas Gir, aplicando modelos de regressão aleatória Estimates of genetic parameters for milk yield and persistency of lactation of Gyr cows, applying random regression models

Revista Brasileira de Zootecnia, 2008
Com o objetivo de estimar parâmetros genéticos para a produção de leite no dia do controle (PLDC), foram usadas as 2.440 primeiras lactações de vacas da raça Gir leiteira, com partos registrados entre 1990 e 2005.
Luis Gabriel González Herrera, Lenira El Faro, Lucia Galvão de Albuquerque, Tonhati Humberto, Carlos Henrique Cavallari Machado   +4 more
doaj   +1 more source

Genetic (co-)variation of methane emissions, efficiency, and production traits in Danish Holstein cattle along and across lactations

Journal of Dairy Science, 2022
: Methane emissions in ruminant livestock has become a hot topic, given the pressure to reduce greenhouse gas emissions drastically in the European Union over the next 10 to 30 yr.
C.I.V. Manzanilla-Pech, G.F. Difford, P. Løvendahl, R.B. Stephansen, J. Lassen   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source