Results 51 to 60 of about 1,906,785 (292)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Bias in genetic evaluation using random regression test-day model

Agricultural and Food Science, 2008
The effect of an upgraded Finnish evaluation model on bias in estimated breeding values for protein yield was investigated. Evaluations based on repeatability animal model and on random regression test-day model without and with heterogeneous variance ...
M. LIDAUER, E.A. MÄNTYSAARI
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Goodness of Fit Tests in Random Coefficient Regression Models [PDF]

Annals of the Institute of Statistical Mathematics, 1999
Random coefficient regressions have been applied in a wide range of fields, from biology to economics, and constitute a common frame for several important statistical models. A nonparametric approach to inference in random coefficient models was initiated by Beran and Hall.
Delicado, Pedro, Romo, Juan
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Genetic parameters for somatic cell score in the first three lactations of Czech Holstein and Fleckvieh breeds using a random regression model

Czech Journal of Animal Science, 2011
A multiple-lactation random regression model was applied to test-day somatic cell score (SCS) records from the first three lactations of Czech Holstein and Fleckvieh cows.
L. Zavadilová, J. Wolf, M. Štípková, E. Němcová, J. Jamrozik   +4 more
doaj   +1 more source

Adapting to Unknown Smoothness by Aggregation of Thresholded Wavelet Estimators [PDF]

, 2006
We study the performances of an adaptive procedure based on a convex combination, with data-driven weights, of term-by-term thresholded wavelet estimators. For the bounded regression model, with random uniform design, and the nonparametric density model,
Chesneau, Christophe, Lecué, Guillaume
core   +4 more sources

Persistency of lactation using random regression models and different fixed regression modeling approaches [PDF]

Revista Brasileira de Zootecnia, 2012
Milk yield test-day records on the first three lactations of 25,500 Holstein cows were used to estimate genetic parameters and predict breeding values for nine measures of persistency and 305-d milk yield in a random regression animal model using two criteria to define the fixed regression.
Cobuci, Jaime Araujo, Costa, Claudio Napolis   +1 more
openaire   +5 more sources