Results 71 to 80 of about 706,502 (262)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Random Forest Regression May Become the Optimal Regression Model for Osteoarthritis of the Knee in Elderly, in the Context of Embodied Cognition and Psychosomatic Medicine

Journal of Multidisciplinary Healthcare
Guangyuan Ma,1,* Junjie Chen,2,3,* Jingchi Li,2,3 Hui Shi,1 Yi Chen1 1School of Humanities and Management, Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Department of Orthopedics, The Affiliated Traditional ...
Ma G, Chen J, Li J, Shi H, Chen Y
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Random regression analyses using B-splines to model growth of Australian Angus cattle

Genetics Selection Evolution, 2005
Regression on the basis function of B-splines has been advocated as an alternative to orthogonal polynomials in random regression analyses. Basic theory of splines in mixed model analyses is reviewed, and estimates from analyses of weights of Australian ...
Meyer Karin
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Random regression analyses using B-spline functions to model growth of Nellore cattle

Animal, 2012
The objective of this study was to estimate (co)variance components using random regression on B-spline functions to weight records obtained from birth to adulthood.
A.A. Boligon, M.E.Z. Mercadante, R.B. Lôbo, F. Baldi, L.G. Albuquerque   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Longitudinal genome-wide association analysis using a single-step random regression model for height in Japanese Holstein cattle. [PDF]

JDS Commun, 2023
Baba T, Morota G, Kawakami J, Gotoh Y, Oka T, Masuda Y, Brito LF, Cockrum RR, Kawahara T.   +8 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Applicability of single-step genomic evaluation with a random regression model for reproductive traits in turkeys (Meleagris gallopavo). [PDF]

Front Genet, 2022
Makanjuola BO, Abdalla EA, Wood BJ, Baes CF.   +3 more
europepmc   +1 more source