Results 81 to 90 of about 706,502 (262)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Genetic parameters for test-day model with random regressions for production traits of Czech Holstein cattle

Czech Journal of Animal Science, 2005
Multiple-lactation random regression model was applied to test-day records of milk, fat and protein yields in the first three lactations of the Czech Holstein breed.
L. Zavadilová, J. Jamrozik, L.R. Schaeffer   +2 more
doaj   +1 more source

Random Regression Model for Genetic Evaluation and Early Selection in the Iranian Holstein Population. [PDF]

Animals (Basel), 2021
Salimiyekta Y, Vaez-Torshizi R, Abbasi MA, Emmamjome-Kashan N, Amin-Afshar M, Guo X, Jensen J.   +6 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A Random Regression Model Based on a Single-Step Method for Improving the Genomic Prediction Accuracy of Residual Feed Intake in Pigs. [PDF]

Front Genet, 2021
Wang Y, Diao C, Kang H, Hao W, Mrode R, Chen J, Liu J, Zhou L.   +7 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Correction: Salimiyekta et al. Random Regression Model for Genetic Evaluation and Early Selection in the Iranian Holstein Population. Animals 2021, 11, 3492. [PDF]

Animals (Basel), 2022
Salimiyekta Y, Vaez-Torshizi R, Abbasi MA, Emmamjome-Kashan N, Amin-Afshar M, Guo X, Jensen J.   +6 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Early genetic selection of Spanish Trotter Horses by new precocity criteria

Italian Journal of Animal Science
National trotting races held in Spain between 1990–2022 were used to estimate genetic para-meters for 5 precocity criteria: age at first ranked race (AFR), age when the animal reached 50% of ranked races (A50%), age when the animal reached the first 10 ...
María Ripollés-Lobo, Davinia Isabel Perdomo-González, María Dolores Gómez, Antonio Molina, Mercedes Valera   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source