Results 71 to 80 of about 2,532,241 (263)

Research on the Charging Load Calculation Method for Electric Vehicle Cluster

open access: yes南方能源建设
[Introduction] The widespread adoption of electric vehicles (EVs) enhances environmental sustainability during travel, yet it simultaneously elevates strain on the mains supply.
Lei YOU, Xiaoming JIN, Yun LIU
doaj   +1 more source

Inference in economic experiments

open access: yesEconomics: Journal Articles, 2020
Replication crisis and debates about p-values have raised doubts about what we can statistically infer from research findings, both in experimental and observational studies.
Hirschauer Norbert   +3 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Estimators in simple random sampling: Searls approach [PDF]

open access: yesSongklanakarin Journal of Science and Technology (SJST), 2013
This paper investigates four new estimators in simple random sampling: biased sample mean, ratio estimator and two linear regression estimators, using known coefficients of variation of the study variable and auxiliary variable. The properties of the new
Jirawan Jitthavech   +1 more
doaj  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Simulation-Based Inference: Random Sampling vs. Random Assignment? What Instructors Should Know

open access: yesJournal of Statistics and Data Science Education
“Simulation-based inference” is often considered a pedagogical strategy for helping students develop inferential reasoning, for example, giving them a visual and concrete reference for deciding whether the observed statistic is unlikely to happen by ...
Beth Chance   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

OPTIMAL RANDOM SAMPLING DESIGNS IN RANDOM FIELD SAMPLING [PDF]

open access: yes
A Horvitz-Thompson predictor is proposed for spatial sampling when the characteristic of interest is modeled as a random field. Optimal sampling designs are deduced under this context. Fixed and variable sample size are considered.
Fernando Ávila, José E. Rodríguez
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Spatial Random Sampling: A Structure-Preserving Data Sketching Tool

open access: yes, 2017
Random column sampling is not guaranteed to yield data sketches that preserve the underlying structures of the data and may not sample sufficiently from less-populated data clusters.
Atia, George, Rahmani, Mostafa
core   +1 more source

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