Results 71 to 80 of about 707,184 (259)

Adaptive Optimized Pattern Extracting Algorithm for Forecasting Maximum Electrical Load Duration Using Random Sampling and Cumulative Slope Index

Energies, 2018
Load forecasting techniques can be an essential method to save energy and shave peak loads in order to improve energy efficiency and maintain the stability of a power grid.
Jinseok Kim, Hyungseop Hong, Ki-Il Kim
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Species composition and diversity of tree species along an altitudinal gradient in Sewa catchment of north-western Himalayas, Jammu and Kashmir, India

Environment Conservation Journal, 2012
Species diversity along altitudinal and latitudinal gradient differs in different tree layers at different scales. Thirteen community groups characterized by different dominants in the tree layer were encountered within an altitudinal range of 580 m asl
Anil K. Raina, Neeraj Sharma
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An Efficient and Stable Registration Framework for Large Point Clouds at Two Different Moments

Sensors
Point cloud registration plays a great role in many application scenarios; however, the registration of large-scale point clouds for actual different moments suffers from the problems of low efficiency, low accuracy, and a lack of stability.
Guangxin Zhao, Jinlong Li, Jingyi Xi, Lin Luo   +3 more
doaj   +1 more source

Fast Ordered Sampling of DNA Sequence Variants

G3: Genes, Genomes, Genetics, 2018
Explosive growth in the amount of genomic data is matched by increasing power of consumer-grade computers. Even applications that require powerful servers can be quickly tested on desktop or laptop machines if we can generate representative samples from ...
Anthony J. Greenberg
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Ein (halb-)automatisiertes Prüfungstool für semesterbegleitende Prüfungen im Fach Biometrie (Q1) im Medizinstudium [A (semi-)automatic tool for semester accompanying exams in the biometry course in medical studies]

GMS Medizinische Informatik, Biometrie und Epidemiologie, 2013
[english] During every summer term at Ulm University the obligatory course of biometry (Q1) is taught in a PC pool using the statistical software SAS Analyst.
Muche, Rainer, Janz, Brigitte, Einsiedler, Beate, Mayer, Benjamin   +3 more
doaj   +1 more source