Results 101 to 110 of about 698,130 (312)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Total or Partial Knee Arthroplasty Trial - TOPKAT : study protocol for a randomised controlled trial [PDF]
, 2013 Peer reviewedPublisher ...
Arden, Nigel +11 more
core +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Understanding controlled trials: Baseline imbalance in randomised controlled trials
BMJ, 1999 In a controlled trial randomisation ensures that allocation of patients to treatments is left purely to chance. The characteristics of patients that may influence outcome are distributed between treatment groups so that any difference in outcome can be assumed to be due to the intervention.
Roberts, C., Torgerson, D. J.
openaire +4 more sources
Text messaging reminders for influenza vaccine in primary care: a cluster randomised controlled trial (TXT4FLUJAB) [PDF]
, 2015 Research tools used in the TXT4FLUJAB randomised controlled trial. These include a study protocol, patient questionnaire, practice questionnaire and instructions for its ...
Chadborn, Tim +7 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Understanding controlled trials: Randomisation methods: concealment
BMJ, 1999 Randomisation is the best method removing selection bias between two groups of patients.1 However, the process of randomisation can be compromised such that the allocation results in biased groups of patients. A trial which has had its randomisation compromised may apparently show a treatment effect that is entirely due to biased allocation.
Torgerson, DJ, Roberts, C.
openaire +4 more sources
Theory of planned behaviour variables and objective walking behaviour do not show seasonal variation in a randomised controlled trial [PDF]
, 2014 BACKGROUND: Longitudinal studies have shown that objectively measured walking behaviour is subject to seasonal variation, with people walking more in summer compared to winter.
French, D.P., Williams, Stefanie
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Spirometry to manage asthma in children: study protocol for a randomised controlled trial (SPIROMAC)
TrialsBackground Asthma affects over 1 million children across the UK, and preventative treatment is guided subjectively by patient symptoms. Spirometry is an objective test of lung function and can be used in children to guide treatment.
Victoria Bell +13 more
doaj +1 more source