Results 111 to 120 of about 702,734 (359)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms and evaluation of other pregnancy complications

Efficacy and Mechanism Evaluation, 2016
Background: Maternal obesity is associated with high birthweight, obesity and premature mortality in adult offspring, probably as a result of maternal hyperglycaemia and insulin resistance.
Carolyn A Chiswick, Rebecca M Reynolds, Fiona C Denison, Amanda J Drake, Shareen Forbes, David E Newby, Brian R Walker, Siobhan Quenby, Susan Wray, Andrew Weeks, Hany Lashen, Aryelly Rodriguez, Gordon D Murray, Sonia Whyte, Ruth Andrew, Natalie Homer, Scott Semple, Calum Gray, Marian C Aldhous, Karen Noble, Sarah Cunningham-Burley, Alice Keely, Jane E Norman   +22 more
doaj   +1 more source

Cost effectiveness of community leg ulcer clinics: randomised controlled trial [PDF]

, 1998
Objectives: To establish the relative cost effectiveness of community leg ulcer clinics that use four layer compression bandaging versus usual care provided by district nurses.
Brereton, L.M.L., Brooker, C.G.D., Collins, K.A., Dixon, S., Morrell, C.J., Peters, J., Walters, S.J.   +6 more
core   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Randomised controlled trial of specialist nurse intervention in heart failure [PDF]

, 2001
<p>Objectives. To determine whether specialist nurse intervention improves outcome in patients with chronic heart failure.</p> <p>Design. Randomised controlled trial.</p> <p>Setting.
Blue, L., Connolly, E., Davie, A.P., Ford, I., Lang, E., McDonagh, T.A., McMurray, J.J.V., Morrison, C., Murdoch, D.R., Norrie, J., Petrie, M.C., Round, C.E.   +11 more
core   +2 more sources

Is the randomised controlled trial the best?

South African Journal of Obstetrics and Gynaecology, 2014
Different study formats are preferred for different research objectives. Randomised controlled trials (RCTs) have a greater ability to test efficacy than other methods, but RCTs can have many limitations. These limitations should be explored, assessed and exposed.
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Testing the activitystat hypothesis: a randomised controlled trial protocol

BMC Public Health, 2012
Background The activitystat hypothesis proposes that when physical activity or energy expenditure is increased or decreased in one domain, there will be a compensatory change in another domain to maintain an overall, stable level of physical activity or ...
Gomersall Sjaan, Maher Carol, Norton Kevin, Dollman Jim, Tomkinson Grant, Esterman Adrian, English Coralie, Lewis Nicole, Olds Tim   +8 more
doaj   +1 more source

Larval therapy for leg ulcers (VenUS II) : randomised controlled trial [PDF]

, 2009
Objective To compare the clinical effectiveness of larval therapy with a standard debridement technique (hydrogel) for sloughy or necrotic leg ulcers. Design Pragmatic, three armed randomised controlled trial.
Bland, J. Martin, Cullum, Nicky, Dowson, Christopher G., Dumville, Jo C., HASH(0x55aa08b64cf0), Iglesias, Cynthia, Mitchell, Joanne L., Nelson, E. Andrea, Soares, Marta O., Torgerson, David J., Worthy, Gill   +10 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source