Results 111 to 120 of about 760,498 (359)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Singing classes for chronic obstructive pulmonary disease: a randomized controlled trial
BMC Pulmonary Medicine, 2012 Background There is some evidence that singing lessons may be of benefit to patients with chronic obstructive pulmonary disease (COPD). It is not clear how much of this benefit is specific to singing and how much relates to the classes being a group ...
Lord Victoria M +12 more
doaj +1 more source
The challenges faced in the design, conduct and analysis of surgical randomised trials [PDF]
, 2009 Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the ...
Cook, Jonathan Alistair
core
Text messaging reminders for influenza vaccine in primary care: a cluster randomised controlled trial (TXT4FLUJAB) [PDF]
, 2015 Research tools used in the TXT4FLUJAB randomised controlled trial. These include a study protocol, patient questionnaire, practice questionnaire and instructions for its ...
Chadborn, Tim +7 more
core +2 more sources
Understanding controlled trials: Randomisation methods: concealment
BMJ, 1999 Randomisation is the best method removing selection bias between two groups of patients.1 However, the process of randomisation can be compromised such that the allocation results in biased groups of patients. A trial which has had its randomisation compromised may apparently show a treatment effect that is entirely due to biased allocation.
Torgerson, DJ, Roberts, C.
openaire +4 more sources
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A Randomised Controlled Trial [PDF]
, 2015 Liver surgery is still associated with a high rate of morbidity and mortality. We aimed to compare different haemodynamic treatments in liver surgery. In a prospective, blinded, randomised, controlled pilot trial patients undergoing liver resection were ...
Feldheiser, Aarne +8 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Trials, 2011 Background Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are ...
Parsons Nicholas R +3 more
doaj +1 more source
Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomised controlled trial (RCT) [PDF]
, 2009 Trifon G. Lainas +6 more
openalex +1 more source