Results 121 to 130 of about 698,130 (312)

Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trial

Trials, 2011
Background Late onset neonatal sepsis (LOS) with the mortality of 17 to 27% is still a serious disease. Meropenem is an antibiotic with wide antibacterial coverage.
de Cabre Vincent, Esposito Susanna, Standing Joseph, Metsvaht Tuuli, Heath Paul T, Trafojer Ursula MT, Lutsar Irja, Oeser Clarissa, Aboulker Jean-Pierre   +8 more
doaj   +1 more source

Randomised controlled trials are important

BMJ, 1999
EDITOR—Cranberg's arguments against controlled trials and in favour of historical controls supported by data on matching for known risk factors are seriously flawed.1 There are at least four fallacies. Firstly, the matching procedures …
openaire   +3 more sources

A falls prevention programme to improve quality of life, physical function and falls efficacy in older people receiving home help services: study protocol for a randomised controlled trial [PDF]

, 2017
BACKGROUND: Falls and fall-related injuries in older adults are associated with great burdens, both for the individuals, the health care system and the society. Previous research has shown evidence for the efficiency of exercise as falls prevention.
A Bandura, A Dadgari, A Saletti, A Vuillemin, AC Scheffer, AF Ambrose, AJ Campbell, AP Vivanti, Astrid Bergland, B Meinow, B Senn, B Vellas, C Luthy, C Meyer, C Sherrington, C-H Chou, CJ Jones, CMA Marques-Vieira, D Altman, Dawn A. Skelton, DM Landers, DM Peters, E McAuley, E McAuley, E McAuley, E McInnes, ER Vieira, ET Petridou, F El-Khoury, FB Gillison, G Salkeld, GA Kelley, HC Kraemer, I Vikman, JH Loge, K Christensen, K Delbaere, K Frändin, K Hawkins, K Haywood, KF Schulz, KF Schulz, KJ Preacher, KO Berg, L Yardley, LF Hektoen, LS Acree, LZ Rubenstein, M Bonnefoy, M Herdman, M Janssen, M Lawton, M Markle-Reid, M Ory, Maria Bjerk, MC Robertson, N Vries De, PC Fletcher, PC Fletcher, R Brooks, R Elkan, R Forkan, S Heydarnejad, S Hollis, S Michie, S Vaapio, SE Lamb, SE Lamb, SM White, SS Vaapio, T Brovold, The EuroQol Group, The WHOQOL Group, Therese Brovold, TN Tombaugh, Y Guigoz, Y Hellström, Y Netz   +77 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Topical analgesia for acute otitis media [PDF]

, 2006
BACKGROUND: Acute otitis media (AOM) is a spontaneously remitting disease for which pain is the most distressing symptom. Antibiotics are now known to have less benefit than previously assumed.OBJECTIVES: To assess the effectiveness of topical analgesia ...
Del Mar, C, Dooley, L, Foxlee, R, Johansson, A, Wejfalk, J   +4 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A randomised controlled trial to compare the clinical and cost-effectiveness of prism glasses, visual search training and standard care in patients with hemianopia following stroke: a protocol [PDF]

, 2014
INTRODUCTION: Homonymous hemianopia is a common and disabling visual problem after stroke. Currently, prism glasses and visual scanning training are proposed to improve it.
Barrett, Black, Bouwmeester, Bowers, Department of Health, Dombovy, Giorgi, Gray, Jones, Jongbloed, Kaplan, Kerkhoff, Lancaster, Machin, Pambakian, Peli, Pollock, Pollock, Pollock, Ramrattan, Riggs, Rossi, Rowe, Rowe, Rowe, Royal College of Physicians Intercollegiate Stroke Working Party, Schofield   +26 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source