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The Internet and randomised controlled trials
International Journal of Medical Informatics, 1997Several factors constrain the implementation of Randomised Controlled Trials (RCTs). To obtain large sample sizes a multicentred multinational trial may be necessary or a long sampling period. The larger the trial the larger is the unit cost. To allow larger sample sizes, shorter sampling periods and lower unit costs, new methods are needed.
J Oldham, M.A. Kelly
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The Objectives of a Randomised Controlled Trial
1983A trial may be conceived to test more than one hypothesis but it is good practice to determine one or a limited set of major objectives. For example, an investigator may be interested in a trial of a new antihypertensive drug in elderly patients. The major objective could be either to demonstrate the efficacy of the drug in lowering blood pressure or ...
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Spotlight on Randomised Controlled Trials
Nursing in Critical Care, 2022Lyvonne N, Tume, Josef, Trapani
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Sample size calculation for stepped wedge and other longitudinal cluster randomised trials
Statistics in Medicine, 2016Richard Hooper+2 more
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