Results 71 to 80 of about 667,561 (138)

Managing Injuries of the Neck Trial (MINT) : design of a randomised controlled trial of treatments for whiplash associated disorders [PDF]

, 2007
Background: A substantial proportion of patients with whiplash injuries develop chronic symptoms. However, the best treatment of acute injuries to prevent long-term problems is uncertain.
A Donner, Ala Szczepura, Anil Gumber, AP Verhagen, Deborah Ashby, Emma J Withers, Esther M Williamson, G Kjellman, H Sarig-Bahat, J Klaber Moffett, L Barnsley, LJ Stovner, M Rosenfeld, Mark A Williams, Martin R Underwood, Matthew W Cooke, MGM Hunink, P Cote, R Evans, R Mayou, Sarah E Lamb, SB Galasko, Shahrul Mt Isa, Simon Gates, SJ Pocock, SM Eldridge, SM Eldridge, T McClune, TSO, WO Spitzer   +29 more
core   +3 more sources

Estimating the probability of demonstrating vaccine efficacy in the declining Ebola epidemic: a Bayesian modelling approach. [PDF]

, 2015
OBJECTIVES: We investigate the chance of demonstrating Ebola vaccine efficacy in an individually randomised controlled trial implemented in the declining epidemic of Forécariah prefecture, Guinea.
Camacho, Anton, Edmunds, W John, Eggo, Rosalind M, Funk, Sebastian, Kucharski, Adam J, Watson, Conall H   +5 more
core   +1 more source

Quality of randomised controlled trials in dentistry

International Dental Journal, 2011
Randomised controlled trials (RCTs) are regarded as the best study designs to test the efficacy of medical and dental intervention. Many reports, however, have shown that at the moment the quality of dental RCT reports is still poor, and further efforts to improve it are necessary.
I. Cioffi, FARELLA, MAURO
openaire   +4 more sources

Vibrating vaginal balls to improve pelvic floor muscle performance in women after childbirth: a protocol for a randomised controlled feasibility trial [PDF]

, 2015
AIM: This paper presents a feasibility trial protocol the purpose of which is to prepare for a future randomised controlled trial to determine the effectiveness of vibrating vaginal pelvic floor training balls for postpartum pelvic floor muscle ...
Abrams, Avery, Baracho, Baytur, Borello-France, Boyle, Bässler, Bø, Bø, Bø, Bø, Bø, Bø, Bø, Chan, Chiarelli, Denzin, Dietz, Diez-Itza, Diez-Itza, Duan, Efird, Eldridge, Fischer, Frawley, Friedman, Glavind, Hahn, Hall, Herbison, Higgins, Hilde, Hundley, Hägglund, Koelbl, Lagro-Janssen, Margalith, Marshall, Meinert, Mørkved, Mørkved, Mørkved, National Collaborating Centre for Women's and Children's Health, O'Reilly, Oblasser, Oppenheim, Sahlin, Sigurdardottir, Sim, Test-Club-Bericht, Thibault-Gagnon, Thom, Udier, Wai, Wilson, Zetterstrom   +55 more
core   +1 more source

Neonatal azithromycin administration to prevent infant mortality: study protocol for a randomised controlled trial. [PDF]

, 2019
IntroductionBiannual mass azithromycin distribution to children aged 1-59 months has been shown to reduce all-cause mortality. Children under 28 days of age were not treated in studies evaluating mass azithromycin distribution for child mortality due to ...
Bagagnan, Cheik, Bountogo, Mamadou, Brogdon, Jessica, Coulibaly, Boubacar, Doan, Thuy, Godwin, William W, Lebas, Elodie, Lietman, Thomas M, Lin, Ying, NAITRE Study Group, Nebie, Eric, Oldenburg, Catherine E, Ouattara, Mamadou, Porco, Travis, Sie, Ali, Zabre, Pascal   +15 more
core  

Can we evaluate population screening strategies in UK general practice? A pilot randomised controlled trial comparing postal and opportunistic screening for genital chlamydial infection [PDF]

, 2005
STUDY OBJECTIVE: To assess whether opportunistic and postal screening strategies for Chlamydia trachomatis can be compared with usual care in a randomised trial in general practice DESIGN: Feasibility study for a randomised controlled trial. SETTING:
Craig, N., Fitzpatrick, B., MacDonald, A., McConnachie, A., Reid, M., Scoular, A., Senok, A., Wilson, P.   +7 more
core   +2 more sources

Comparison of the collagen haemostat Sangustop(R) versus a carrier-bound fibrin sealant during liver resection; ESSCALIVER-study [PDF]

, 2010
Background: Haemostasis in liver surgery remains a challenge despite improved resection techniques. Oozing from blood vessels too small to be ligated necessitate a treatment with haemostats in order to prevent complications attributed to bleeding.
A Frilling, C Broelsch, Christian Moench, G Piaggio, Godehard Hoexter, Hanns-Peter Knaebel, I Takacs, J Kruger, M Schwartz, RG Newcombe, S Siemer, TW Kraus, Valentin Hermanutz, WC Chapman, WO Bechstein, Wolf O Bechstein   +15 more
core   +3 more sources

Supervised variable selection in randomised controlled trials prior to exploration of treatment effect heterogeneity: an example from severe malaria [PDF]

arXiv, 2019
Exploration of treatment effect heterogeneity (TEH) is an increasingly important aspect of modern statistical analysis for stratified medicine in randomised controlled trials (RCTs) as we start to gather more information on trial participants and wish to maximise the opportunities for learning from data.
arxiv  

Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers. [PDF]

, 2015
BACKGROUND: Central to the design of a randomised controlled trial is the calculation of the number of participants needed. This is typically achieved by specifying a target difference and calculating the corresponding sample size, which provides ...
Altman, Douglas G., Briggs, Andrew H., Buckley, Brian, Cook, Jonathan A., DELTA group, Fayers, Peter, Fergusson, Dean, Ford, Ian, Harvey, Ian M., Hislop, Jenni, Norrie, John D., Ramsay, Craig R., Vale, Luke D.   +12 more
core   +5 more sources

Designing and evaluating advanced adaptive randomised clinical trials: a practical guide [PDF]

arXiv
Background Advanced adaptive randomised clinical trials are increasingly used. Compared to their conventional counterparts, their flexibility may make them more efficient, increase the probability of obtaining conclusive results without larger samples than necessary, and increase the probability that individual participants are allocated to more ...
arxiv