Results 71 to 80 of about 760,498 (359)

Gross Domestic Product (GDP) and productivity of schizophrenia trials: an ecological study [PDF]

, 2003
The 5000 randomised controlled trials (RCTs) in the Cochrane Schizophrenia Group's database affords an opportunity to research for variables related to the differences between nations of their output of schizophrenia trials.
B Thornley, Carina Moll, CE Adams, Clive Elliott Adams, Hany George El-sayeh, L Sims, Mark Fenton, P Armitage, Stephanie Bartsch, T Inada, TA Furukawa, Ursula Gessler   +11 more
core   +3 more sources

Understanding controlled trials: Why are randomised controlled trials important? [PDF]

BMJ, 1998
Randomised controlled trials are the most rigorous way of determining whether a cause-effect relation exists between treatment and outcome and for assessing the cost effectiveness of a treatment. They have several important features: Other study designs, including non-randomised controlled …
Sibbald, B., Roland, M.
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A randomised controlled trial to evaluate and optimize the use of antiplatelet agents in the perioperative management in patients undergoing general and abdominal surgery- the APAP trial (ISRCTN45810007)

BMC Surgery, 2011
Background Due to the increase of cardiovascular diseases acetylsalicylic acid (ASA) has become one of the most frequently prescribed drugs these days.
Rahbari Nuh N, Contin Pietro, Rakow Anastasia, Reissfelder Christoph, Antolovic Dalibor, Büchler Markus W, Weitz Jürgen, Koch Moritz   +7 more
doaj   +1 more source

Study protocol: can a school gardening intervention improve children's diets? [PDF]

, 2012
BACKGROUND: The current academic literature suggests there is a potential for using gardening as a tool to improve children's fruit and vegetable intake.
A Demas, A Magarey, A Timperio, AW Fogarty, Birch, C Knai, Charlotte EL Evans, CL Perry, CL Perry, D Ciliska, D Gross, E Bere, E Bere, Foundation BN, G Auld, J Baranowski, J Connolly, J Gregory, J Rasbash, J Wardle, Janet E Cade, JD Skinner, JJ Reilly, JK Ransley, JO Fisher, Joan K Ransley, K Patrick, KD Reynolds, KW Cullen, KW Cullen, L Blanchette, L Wells, M Campbell, M Maynard, M Nelson, M Prelip, Mark Conner, Meaghan S Christian, MR Singer, MW Howerton, National Foundation for Educational Research, P Sahota, R Perera, S Somerset, S Somerset, SA French, SJ Te Velde, ST Yeo, StataCorp, World Cancer Research Fund, World Health Organization   +50 more
core   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Oral nitrate supplementation improves cardiovascular risk markers in COPD: ON-BC, a randomised controlled trial [PDF]

, 2023
Ali Alasmari, Abdullah S Alsulayyim, Saeed M. Alghamdi, Keir Philip, Sara Buttery, Winston Banya, Michael I. Polkey, Paul C. Armstrong, Matthew Rickman, Timothy D. Warner, Jane A. Mitchell, Nicholas S Hopkinson   +11 more
openalex   +1 more source

Computerised speechreading training for deaf children: A randomised controlled trial [PDF]

, 2019
Purpose: We developed and evaluated in a randomised controlled triala computerised speechreading training programme to determine a) whether it is possible to train speechreading in deaf children and b) whether speechreading training results in ...
Amelia Ralph-Lewis, Bergeron J. P., Charles Hulme, Chris Donlan, Elizabeth Worster, Elliot C. D., Fiona Kyle, Hannah Pimperton, Hulme C., Indie Beedie, Kyle F. E., Mairéad MacSweeney, Margaret Harris, Qi S., Rachel Rees, Snowling M. J., Stackhouse J., Van Uden A., Worster E.   +18 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Open versus laparoscopic left lateral hepatic sectionectomy within an enhanced recovery ERAS® programme (ORANGE II – Trial): study protocol for a randomised controlled trial

Trials, 2012
Background The use of lLaparoscopic liver resection in terms of time to functional recovery, length of hospital stay (LOS), long-term abdominal wall hernias, costs and quality of life (QOL) has never been studied in a randomised controlled trial ...
van Dam Ronald M, Wong-Lun-Hing Edgar M, van Breukelen Gerard JP, Stoot Jan HMB, van der Vorst Joost R, Bemelmans Marc HA, Damink Steven WM, Lassen Kristoffer, Dejong Cornelis HC   +8 more
doaj   +1 more source