Results 81 to 90 of about 667,561 (138)

Adding new experimental arms to randomised clinical trials: impact on error rates [PDF]

arXiv, 2019
Background: Experimental treatments pass through various stages of development. If a treatment passes through early phase experiments, the investigators may want to assess it in a late phase randomised controlled trial. An efficient way to do this is adding it as a new research arm to an ongoing trial.
arxiv  

Instrumental variable approaches for estimating complier average causal effects on bivariate outcomes in randomised trials with non-compliance [PDF]

arXiv, 2016
In Randomised Controlled Trials (RCT) with treatment non-compliance, instrumental variable approaches are used to estimate complier average causal effects. We extend these approaches to cost-effectiveness analyses, where methods need to recognise the correlation between cost and health outcomes.
arxiv  

Randomised controlled trials [PDF]

Eye, 1995
openaire   +3 more sources

Data Fusion for Heterogeneous Treatment Effect Estimation with Multi-Task Gaussian Processes [PDF]

arXiv
Bridging the gap between internal and external validity is crucial for heterogeneous treatment effect estimation. Randomised controlled trials (RCTs), favoured for their internal validity due to randomisation, often encounter challenges in generalising findings due to strict eligibility criteria.
arxiv  

Measurement and predictors of adherence in a trial of HSV suppressive therapy in Tanzania.

, 2009
This study estimates adherence and identifies predictors of good adherence among 1305 Tanzanian women participating in a randomised, double-blind, placebo-controlled trial of HSV suppressive therapy to reduce HIV incidence or genital HIV shedding.
Baisley, Kathy, Changalucha, John, Clayton, Tim, Hambleton, Ian, Hayes, Richard J, Mugeye, Kokugonza, Ross, David A, Rusizoka, Mary, Tanton, Clare, Watson-Jones, Deborah, Weiss, Helen A   +10 more
core   +1 more source

Making all pairwise comparisons in multi-arm clinical trials without control treatment [PDF]

arXiv
The standard paradigm for confirmatory clinical trials is to compare experimental treatments with a control, for example the standard of care or a placebo. However, it is not always the case that a suitable control exists. Efficient statistical methodology is well studied in the setting of randomised controlled trials.
arxiv  

Correction to:Statistical analysis plan for the SOLUTIONS randomised controlled trial with internal pilot: Solution Focused Brief Therapy (SFBT) in 10–17-year-olds presenting at police custody [PDF]

Following the publication of the original article [1], we were notified of a typo in the title. Originally published title: “Statistical analysis plan for the SOLUTIONS randomised controlled trial with internal pilot: Solution Focused Brief Therapy (SFBT)
Badger, Julia, Coulman, Elinor, Flynn, Samantha, Gray, Kylie M., Hastings, Richard P., Langdon, Peter E., Longman, Andrea, Lugg-Widger, Fiona, Moody, Gwenllian, Owen-Jones, Eleri, Patel, Faizan, Playle, Rebecca, Segrott, Jeremy, Thompson, Paul A.   +13 more
core   +1 more source

Randomised controlled trials. [PDF]

BMJ, 1980
openaire   +3 more sources

What is a randomised controlled trial?

Epidemiologia e Psichiatria Sociale, 2009
CIPRIANI, Andrea, Geddes JR
openaire   +5 more sources

A fast, flexible simulation framework for Bayesian adaptive designs -- the R package BATSS [PDF]

arXiv
The use of Bayesian adaptive designs for randomised controlled trials has been hindered by the lack of software readily available to statisticians. We have developed a new software package (Bayesian Adaptive Trials Simulator Software - BATSS for the statistical software R, which provides a flexible structure for the fast simulation of Bayesian adaptive
arxiv