Results 71 to 80 of about 606,124 (320)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Rehabilitation with forage grasses of an area degraded by urban solid waste deposits

Revista Brasileira de Zootecnia, 2012
Dry matter yield and chemical composition of forage grasses harvested from an area degraded by urban solid waste deposits were evaluated. A split-plot scheme in a randomized block design with four replicates was used, with five grasses in the plots and ...
Vanessa Soares Miranda, Karina Guimarães Ribeiro, Alexandre Christófaro Silva, Rosana Cristina Pereira, Odilon Gomes Pereira, Pablo Vidal Torrado, José Sebastião Cunha Fernandes, Maxwel Coura Oliveira   +7 more
doaj   +1 more source

Relative efficiency of alpha lattice design over randomized complete block design in yield trials of chickpea (Cicer arietinum L.) [PDF]

پژوهش‌های حبوبات ایران, 2014
Structure of alpha lattice designs makes removing the effects of incomplete blocks from residual effect of plots, and maximizes precision of comparison between genotypes at the same incomplete block.
Homayoun Kanouni, Mohammad Imtiaz
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Milk Chemical Composition of Dairy Cows Fed Rations Containing Protected Omega-3 Fatty Acids and Fermented Rice Bran [PDF]

, 2013
The research was conducted to investigate the effect of ration containing protected omega-3 and fermented rice bran on chemical composition of dairy milk. The research employed 10 female PFH dairy cows of 2-4 years old with body weight 300-375 kg.
Purnomo, S. H. (S), Sudibya, S. (Sudibya)   +1 more
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Effect of phosphorus and micronutrients on growth and yield of groundnut (Arachis hypogaea L.)

Environment Conservation Journal
An experiment was conducted at the Crop Research Farm (CRF), Department of Agronomy, SHUATS, Prayagraj, U.P, India, during the Kharif season of 2023.
Namrata Minz, Karishma Singh , Joy Dawson   +2 more
doaj   +1 more source

The impact of deep versus standard neuromuscular block on intraoperative safety during laparoscopic surgery: an international multicenter randomized controlled double-blind strategy trial — EURO-RELAX TRIAL

Trials, 2021
Background Muscle relaxants are routinely used during anesthesia to facilitate endotracheal intubation and to optimize surgical conditions. However, controversy remains about the required depth of neuromuscular block (NMB) needed for optimal surgical ...
Maarten Honing, Gabby Reijnders-Boerboom, Salome Dell-Kuster, Monique van Velzen, Chris Martini, Franco Valenza, Paolo Proto, Oscar Díaz Cambronero, Suzanne Broens, Ivo Panhuizen, Margot Roozekrans, Thomas Fuchs-Buder, Martijn Boon, Albert Dahan, Michiel Warlé   +14 more
doaj   +1 more source

Chromobacterium violaceum associated with recurrent vaginal discharge among apparently healthy females in Ekpoma, Nigeria [PDF]

, 2007
Seven hundred and two high vaginal swab samples of apparently healthy adult females with recurrent vaginal discharge were collected and analyzed at Searchlight Medical Diagnostic Centre, Ekpoma between July 2003 and August 2005. Isolation, identification
Ezera, Agwu, Godwin Ray Anugboba, Okogun, John Cletus, Ihongbe, Joseph Obiezu Chukwujekwu, Ezeonwumelu, Osamuyime, Igbinovia   +4 more
core   +1 more source

Multi-center clinical trials: Randomization and ancillary statistics

, 2008
The purpose of this paper is to investigate and develop methods for analysis of multi-center randomized clinical trials which only rely on the randomization process as a basis of inference.
Zelen, Marvin, Zheng, Lu
core   +1 more source