Results 81 to 90 of about 606,124 (320)

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Several key issues must be noted in determining postoperative analgesic efficacy of intercostal nerve block for thoracoscopic surgery

Journal of Cardiothoracic Surgery, 2023
The letter to the editor was written in response to “The effect of ultrasound-guided intercostal nerve block on postoperative analgesia in thoracoscopic surgery: a randomized, double-blinded, clinical trial”, which was recently published by Li et al.
Xin-Tao Li, Wen-He Yang, Fu-Shan Xue
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Pengaruh Pemberian Probiotik dalam Pakan terhadap Pertambahan Bobot Badan Kambing Kacang

Jurnal Ilmiah Ilmu-Ilmu Peternakan, 2009
This study was conducted to determine the effects of  probiotic in ration by body weight Kacang goat. This study  used 16 male goat with 1- 1.5 months of age at 10 – 20 kg of body weight.
adriani adriani
doaj   +3 more sources

Inference with interference between units in an fMRI experiment of motor inhibition

, 2017
An experimental unit is an opportunity to randomly apply or withhold a treatment. There is interference between units if the application of the treatment to one unit may also affect other units.
Aron A. R., Chiang-Shan R. Li, Cochran W. G., Conover W. J., Cox D. R., David O., Deshpande J. V., Duann J. R., Dylan S. Small, Fisher R. A., Forstmann B. U., Friston K. J., Friston K. J., Hoeffding W., Hudgens M. G., Lehmann E. L., Lehmann E. L., Li C. S., Lindquist M. A., Lindquist M. A., Lindquist M. A., Neyman J., Neyman J., Neyman J., Orban J., Paul R. Rosenbaum, Puri M. L., Rosenbaum P. R., Rosenbaum P. R., Rosenbaum P. R., Rosenbaum P. R., Rosenbaum P. R., Rubin D. B., Salsburg D. S., Simmonds D. J., Sobel M. E., Stephenson W. R., Stephenson W. R., Tukey J. W., Weiss L., Welch B. L., Xi Luo   +41 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Horseweed (Marestail) Resistance [PDF]

, 2018
Horseweed has documented resistance to EPSPS inhibitors, PSII inhibitors, ALS inhibitors, and PSI inhibitor (Heap, 2018). Glyphosate resistant horseweed moves the herbicide into a vacuole preventing the herbicide from damaging the plant (Ge, 2010).
Dille, J. Anita, Lester, Alec, Rains, Larry   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Randomization techniques in protocols for cluster randomized trials [PDF]

Praxis Medica, 2017
Planning cluster randomized studies requires special attention due to their specific design. To achieve balance on a cluster level as well as on individual level, it is necessary to apply randomization techniques which involve restricted randomization ...
Kostić Mirjana, Stanisavljević Dejana, Ilić Aleksandra, Bukumirić Zoran, Jovanović Marija, Trajković Goran   +5 more
doaj