Results 111 to 120 of about 8,079,813 (317)

Strengthening and stretching for rheumatoid arthritis of the hand (SARAH): design of a randomised controlled trial of a hand and upper limb exercise intervention - ISRCTN89936343 [PDF]

, 2012
Background: Rheumatoid Arthritis (RA) commonly affects the hands and wrists with inflammation, deformity, pain, weakness and restricted mobility leading to reduced function.
Toye, Francine, Lamb, S. E. (Sallie E.), Williamson Esther M, Adams, Jo, Nichols, Vivien P., Heine Peter, McConkey Christopher, Mark A Williams, Nicols, Vivien, Underwood, Martin, Bridle, Christopher, Bridle, C, Lord, J, Bridle, Chris, Esther M Williamson, Joanne Lord, Heine, Peter, Williamson, Esther, Christopher McConkey, Williams, MA, Lamb, Sarah, null null, Heine, Peter J., Dosanjh Sukhdeep, Adams Jo, Francine Toye, Lamb Sarah E, Williams, Mark A., Sukhdeep Dosanjh, Lamb, SE, Chris Bridle, McConkey, Christopher C., Toye, F, Nichols Vivien, Heine, P, Underwood Martin R, Toye Francine, HASH(0x55a6805dc180), Bridle Chris, Williamson, EM, Martin R Underwood, Williams Mark A, Dosanjh, S, Underwood, MR, Jo Adams, Adams, J, Lord, J., McConkey, Christopher, Vivien Nichols, Sarah Trial Team, The, Lord, Joanne, Williams, Mark, Lord Joanne, Dosanjh, Sukhdeep, Nichols, V, Sarah E Lamb, McConkey, C, Peter Heine, Williamson, Esther M.   +58 more
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B4 and leukotriene B5 production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial

, 2014
Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-
Schmidt, E.B., Schmidt, Lone, Thorlacius-Ussing, Ole; id_orcid, Thorlacius-Ussing, O., Erik Schmidt, Ole Thorlacius-Ussing, Rasmussen, Henrik Højgaard, Lundbye-Christensen, S., Lindhorff-Larsen, K., Lindorff Larsen, Karen, Sorensen, L.S., Calder, P.C., Henrik Rasmussen, Søren Lundbye-Christensen, Rasmussen, H.H., Lundbye-Christensen, Søren; id_orcid, Lone Sorensen, Philip. Calder, Calder, Philip C, Schmidt, Erik Berg, Karen Lindorff-Larsen   +20 more
core   +1 more source

The effects of reducing worry in patients with persecutory delusions: study protocol for a randomized controlled trial [PDF]

, 2012
BACKGROUND: Our approach to advancing the treatment of psychosis is to focus on key single symptoms and develop interventions that target the mechanisms that maintain them.
Dunn, Graham, Kingdon David, Helen Startup, David Kingdon, Daniel Freeman, Startup Helen, Freeman Daniel, Dunn Graham, Kingdon, David, Freeman, Daniel, Startup, Helen, Graham Dunn   +11 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Treating Racial Trauma: The Methodology of a Randomized Controlled Trial of the Healing Racial Trauma Protocol

Behavioral Sciences
Cumulative experiences of racism lead to stress and trauma. Racial trauma is associated with compromised functioning across psychological, social, and physical health domains.
Muna Osman, Sophia Gran-Ruaz, Lucia Rios Maia da Silva, Monnica T. Williams   +3 more
doaj   +1 more source

CLUSTER RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTIFACETED ACTIVE STRATEGY TO IMPLEMENT LOW BACK PAIN PRACTICE GUIDELINES; EFFECT ON COMPETENCE, PROCESS OF CARE AND PATIENT OUTCOMES IN PHYSICAL THERAPY [PDF]

, 2013
The study was a cluster randomized controlled trial designed to evaluate the effectiveness of an active strategy to implement practice guidelines for low back pain in physical therapy.
Shenoy, Sonali
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Feasibility randomized controlled trial of cognitive and behavioral interventions for depression symptoms in patients accessing drug and alcohol treatment [PDF]

, 2015
Depressed mood often co-exists with frequent drug and alcohol use. This trial examined the feasibility of screening, recruitment, randomization and engagement of drug and alcohol users in psychological interventions for depression symptoms. A total of 50
Delgadillo, J., Gilbody, Simon, Gore, Stuart, Ekers, D., Gilchrist, G., Delgadillo, Jaime, Ekers, David, Hughes, E., McMillan, D., Gilchrist, Gail; id_orcid, McMillan, Dean, Ali, Shehzad, Gilbody, S., Hughes, Elizabeth, Ali, S., Gilchrist, Gail, Gore, S.   +16 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source