Results 151 to 160 of about 1,847,943 (315)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Observation on the Efficacy of Electroacupuncture for Functional Constipation

针刺研究, 2017
Objective To investigate the therapeutic rule of electroacupuncture(EA)in treating functional constipation.Methods Eighty-eight patients with severe chronic functional constipation were randomized divided into EA(n=45)and shamEA(n=43)groups.Patients in ...
LV Jian-qin, WANG Cheng-wei, LIU Meng-yue, ZHAO Yu, WEN Qian, LI Ning   +5 more
doaj  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

CHOSEN: A Randomized Controlled Feasibility Trial

Journal of the American Heart Association
Background Improving oral health in patients with acutely dysphagic stroke is a plausible approach to prevent pneumonia. We aimed to determine whether a phase 3, definitive trial of oral health care (OHC) treatments, supported by staff education and training, is feasible in stroke unit care ...
Craig J. Smith, Andrew Brand, Zoe Hoare, Eileen Jones, Catherine Davidson, Wendy Westoby, Ian Clements, Fiona Sandom, Clare Gross, Anu Thomas, Lucy Talbot, Narayanamoorthi Saravanan, Marian C. Brady, Peter Langhorne, Giles I. McCracken, Catherine E. Lightbody, Caroline L. Watkins, Paul R. Brocklehurst   +17 more
openaire   +4 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Impact of ICT on Adolescents' Perceptions and Consumption of Substances [PDF]

This paper reports the results of a three-month randomized controlled trial to estimate the impact of an Internet and mobile telephone short message service (SMS) intervention on adolescents’ information about substances and rates of consumption.
Ana Balsa, Nestor Gandelman, Rafael Porzecanski   +2 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Literature Review of Domestic Randomized Controlled Trials for Hominis Placenta Pharmacopuncture

Journal of Acupuncture Research
This study was conducted to analyze research trends, quality, and bias of pharmacopuncture studies, etc., on domestic randomized controlled trials (RCTs) using hominis placenta pharmacopuncture (HPP).
Hea Sun Chun
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Electroacupuncture versus Sham Acupuncture for Perimenopausal Insomnia: A Randomized Controlled Clinical Trial

Nature and Science of Sleep, 2020
Shanshan Li,1,* Zhaoqin Wang,2,* Huangan Wu,3,* Hongyu Yue,1 Ping Yin,1 Wei Zhang,4 Lixing Lao,5 Yiqun Mi,1 Shifen Xu1 1Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071 ...
Li S, Wang Z, Wu H, Yue H, Yin P, Zhang W, Lao L, Mi Y, Xu S   +8 more
doaj