Results 131 to 140 of about 1,017,967 (316)

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI) [PDF]

, 2014
AimDespite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI.
Singh, Satnam, Lim, Pitt O, Christopher Neil (433186), Bruce, M, Broadhurst, Paul, Madhani, Melanie; id_orcid, Nishat Siddiqi (7733786), Schwarz, Konstantin, Awsan, Noman, Jansen, Else, McPherson, Gladys, Dawson, Dana, Slattery, Elaine, Struthers, Allan, McDonald, Alison, Rhodes, Jonathan, Neil, Christopher, Toff, William, Bruce, M., Garg, Deepak, Siddiqi, N, Firoozi, Sami, Kaski, JC, Madhani, M., Nicholas Boon (7733804), Kaski, Juan-Carlo, Sofia Papadopoulou (7733789), Horowitz, J, Bennett, Lorraine, Horowitz, J., Frenneaux, Michael, Boon, N., Bruce, Margaret, Hildick-Smith, David, Lim, P., Neil, C., Nightingale, Peter, Pitt O. Lim (7733795), Graeme MacLennan (275485), Hannah, Andrew, Feelisch, M., Melanie Madhani (3851305), Roberts, Elved, Dawson, D, David Hildick-Smith (7733798), Madhani, M, Kaski, Juan Carlos, Lim, PO, Stewart, Andrew, Cooter, Nina, Rajendran, Sharmalar, Horowitz, John, Lang, Chim, Papadopoulou, Sofia A., NIAMI investigators, Jagpal, Baljit, Cotton, S, Siddiqi, N., Gonzalvez, Fatima, Feelisch, Martin, Madhani, Melanie, Boon, Nicholas, Nicholas Bunce (7733792), Brown, Sue, Roy, David, Bunce, N., Bunce, N, Papadopoulou, S, Dawson, D., Frenneaux, M., Michael Frenneaux (3576296), Davidson, Tracey, Siddiqi, Nishat, Dargie, Henry, Feelisch, M, Neil, C, Dana Dawson (7020656), Hildick-Smith, D., Frenneaux, M, Hildick-Smith, D, Bunce, Nicholas, NIAMI investigators (7733810), Cotton, Seonaidh, Seonaidh Cotton (503485), de Belder, Adam, Papadopoulou, S., Black, Marilyn, Kaski, J., Hogg, Duncan, Dautov, Rustem, Metcalfe, Malcolm, Bogle, Richard, Cotton, S., Boon, N, Martin Feelisch (358503), John Horowitz (7733801), Margaret Bruce (782483), Lim, Pitt O., MacLennan, G, Cotton, Seonaidh Claire, Juan Carlos Kaski (7733807), Maclennan, Graeme, Papadopoulou, Sofia, MacLennan, G.   +103 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Selective Trials: A Principal-Agent Approach to Randomized Controlled Experiments [PDF]

We study the design of randomized controlled experiments in environments where outcomes are significantly affected by unobserved effort decisions taken by the subjects(agents). While standard randomized controlled trials (RCTs) are internally consistent,
Erik Snowberg, Gerard Padro i Miquel, Sylvain Chassang   +2 more
core  

Managing Injuries of the Neck Trial (MINT) : design of a randomised controlled trial of treatments for whiplash associated disorders [PDF]

, 2007
Background: A substantial proportion of patients with whiplash injuries develop chronic symptoms. However, the best treatment of acute injuries to prevent long-term problems is uncertain.
Cooke, MW, Lamb, S. E. (Sallie E.), Williamson Esther M, Cooke, Matthew (Professor of clinical systems design), Ashby Deborah, Lamb, Sarah E, Mark A Williams, Gates, S, Lamb, S. E., Underwood, Martin, Withers, Emma J, Esther M Williamson, Mt Isa, Sharul, Cooke Matthew W, Gumber, Anil, Shahrul Mt Isa, Williamson, Esther, Williams, Mark A, Ashby, D, Gates, Simon, Withers Emma J, Lamb, Sarah, null null, Ala Szczepura, Ashby, Deborah, Simon Gates, Lamb Sarah E, Williams, Mark A., Mt Isa Shahrul, Matthew W Cooke, Underwood, Martin R, Withers, EJ, Anil Gumber, Gumber, A., Underwood Martin R, Emma J Withers, Gumber Anil, Underwood, Martin R., Williamson, Esther M, Szczepura, A, Gumber, A, Mt Isa, S, Martin R Underwood, Williams Mark A, Cooke, Matthew W., Mt Isa, Shahrul, Szczepura, Ala; id_orcid, Underwood, MR, Szczepura, Ala, Cooke, Matthew W, Withers, Emma J., Williams, Mark, Szczepura Ala, Sarah E Lamb, Deborah Ashby, Gates Simon, Isa, Shahrul Mt, Williamson, Esther M.   +57 more
core   +1 more source

A Primer on Randomized Controlled Trials

The Journal of ExtraCorporeal Technology, 2006
Randomized Clinical Trials are held as the gold standard for quantifying the effect of an intervention across two or more groups. In such a trial an intervention is randomly allocated to one of two groups. The benefit of such a trial lies in its ability to establish nearly comparable groups of subjects in all manner except for the effect of the ...
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Efficacy of Early Neonatal Vitamin A Supplementation in Reducing Mortality During Infancy in Ghana, India and Tanzania: Study Protocol for a Randomized Controlled Trial. [PDF]

, 2012
Vitamin A supplementation of 6-59 month old children is currently recommended by the World Health Organization based on evidence that it reduces mortality.
Honorati Masanja, Fontaine Olivier, Bahl, Rajiv, Dube Brinda, Rajiv Bahl, Oleary Maureen, Taneja, Sunita, Fawzi Wafaie, Msham Salum, Martines Jose, NEOVITA Study Author Group, Kirkwood, BR, Bhandari, Nita, Oleary, M, Sam Newton, Salum Msham, Newton Sam, Bhandari, N, Brinda Dube, Bahl, R, Emily Smith, Dube, Brinda, Fawzi, W, Mazumder, S, Sarmila Mazumder, Oleary, Maureen, Shannon, C, Kirkwood Betty R, Betty R Kirkwood, Martines, J, Taneja Sunita, Msham, Salum, Jose Martines, Masanja, H, null null, Olivier Fontaine, Msham, S, Mazumder, Sarmila, Fontaine, O, Nita Bhandari, Edmond, Karen, Ruben, Julia, Sunita Taneja, Kaur Jasmine, Wafaie Fawzi, Smith, E, Masanja Honorati, Taneja, S, Ruben Julia, Yoshida, Sachiyo, Bhandari Nita, Karen Edmond, Caitlin Shannon, Fontaine, Olivier, Smith Emily, Maureen Oleary, Kaur, Jasmine, Ruben, J, Julia Ruben, Fawzi, Wafaie, Newton, S, Newton, Sam, Edmond Karen, Mazumder Sarmila, Martines, Jose, Kirkwood, Betty R., Kirkwood, Betty R, Bahl Rajiv, Jasmine Kaur, Shannon Caitlin, Edmond, K, Sachiyo Yoshida, Masanja, Honorati, Shannon, Caitlin, Smith, Emily, Dube, B, Yoshida, S, Kaur, J, Yoshida Sachiyo   +78 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Zinc Supplementation during Pregnancy: A Randomized Controlled Trial [PDF]

Zinc deficiency during pregnancy has been related to adverse pregnancy outcomes. However, the results of zinc-supplementation trials have not been consistent in improvement of pregnancies outcomes.
مهاجری, منوچهر, امینی ثانی, نیره, شمشیرگران, سید مرتضی, اهدایی وند, فرناز, پورفرضی, فرهاد, صادقیه اهری, سعید   +5 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source