Results 111 to 120 of about 1,017,967 (316)

Randomized phase II study comparing two doses of regorafenib in second-line treatment for advanced hepatocellular carcinoma

JHEP Reports
Background & Aims: The RESORCE trial confirmed regorafenib as a second-line treatment for advanced hepatocellular carcinoma (HCC) in patients who tolerated sorafenib.
Keisuke Koroki, Sadahisa Ogasawara, Sae Yumita, Miyuki Nakagawa, Hiroaki Kanzaki, Kazufumi Kobayashi, Masanori Inoue, Masato Nakamura, Naoya Kanogawa, Takayuki Kondo, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Yuki Shiko, Yoshihito Ozawa, Yosuke Inaba   +15 more
doaj   +1 more source

Revisiting the Randomized Controlled Trial

Pakistan Journal of Medical Sciences, 2017
doi: https://doi.org/10.12669/pjms.333.13221How to cite this:Zulfiqar H. Revisiting the Randomized Controlled Trial. Pak J Med Sci. 2017;33(3):517-518.   doi: https://doi.org/10.12669/pjms.333.13221This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which ...
openaire   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

CHAMP: Cognitive behaviour therapy for health anxiety in medical patients, a randomised controlled trial. [PDF]

, 2011
BACKGROUND: Abnormal health anxiety, also called hypochondriasis, has been successfully treated by cognitive behaviour therapy (CBT) in patients recruited from primary care, but only one pilot trial has been carried out among those attending secondary ...
Smith, Georgina, Cooper, S, Green, J, Wang, D L, Cooper Sylvia, Murphy, David, Byford, Sarah, Salkovskis Paul, Reid, Steven, Mike Crawford, Dupont, S, Dupont Simon, Wang Duolao, Sarah Byford, Byford Sarah, Barrett, Barbara, Green, John, Barbara Barrett, Dupont, Simon, John Green, Cooper, Sylvia, Smith Georgina, Barrett, Barbara; id_orcid, Barrett, B, Byford, Sarah; id_orcid, Georgina Smith, Steven Reid, Tyrer, H, Byford, S, Tyrer, P, Sylvia Cooper, Tyrer Helen, Duolao Wang, Murphy, D, Wang, D, Simon Dupont, Wang, Duolao, Paul Salkovskis, Green John, Smith, G, Crawford, M, Salkovskis, Paul M, Crawford Mike, Salkovskis, Paul, Peter Tyrer, Murphy David, David Murphy, Barrett Barbara, Salkovskis, P, Crawford, Mike, Tyrer Peter, Reid Steven, Helen Tyrer, Byford, S; id_orcid, Tyrer, Helen, Barrett, B; id_orcid, Tyrer, Peter, Reid, S   +57 more
core   +1 more source

Efficacy of Two Doses of Ivermectin Tablet in Treatment of Scabies in Comparison to Once Application of 5% Permethrin Lotion – A Randomized Controlled Trial

Indian Journal of Community Medicine
Background: Scabies may cause community outbreaks without early diagnosis and appropriate treatment. Oral ivermectin offsets some of the challenges associated with topical 5% permethrin application for treating scabies.
Debkumar Pal, Priyamadhaba Behera, Mythry Ravichandran, Dinesh P. Sahu, Chandra S. Sirka, Binod K. Patro, Siddharth Dash, Manish Taywade   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Primary care practice-based care management for chronically ill patients (PraCMan): study protocol for a cluster randomized controlled trial [ISRCTN56104508] [PDF]

, 2011
Background: Care management programmes are an effective approach to care for high risk patients with complex care needs resulting from multiple co-occurring medical and non-medical conditions.
Baldauf Annika, Gerlach, Ferdinand M., Joachim Szecsenyi, Beyer Martin, Szecsenyi, Joachim, Gerlach Ferdinand M, Peters-Klimm Frank, Ferdinand M Gerlach, Peters-Klimm, Frank, Erler, Antje, Cornelia Mahler, Rochon Justine, Gensichen Jochen, Mahler Cornelia, Freund, Tobias, Martin Beyer, Antje Erler, Szecsenyi Joachim, Gensichen, Jochen, Freund Tobias, Beyer, Martin, Justine Rochon, Mahler, Cornelia, Baldauf, Annika, Tobias Freund, Frank Peters-Klimm, Jochen Gensichen, Rochon, Justine, Erler Antje, Annika Baldauf   +29 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Assessing water filtration and safe storage in households with young children of HIV-positive mothers: a randomized, controlled trial in Zambia. [PDF]

, 2012
BACKGROUND: Unsafe drinking water presents a particular threat to people living with HIV/AIDS (PLHIV) due to the increased risk of opportunistic infections, diarrhea-associated malabsorption of essential nutrients, and increased exposure to untreated ...
Clasen, Thomas, Peletz, R, Simunyama Martin, Sarenje Kelvin, Simunyama, Martin, Sarenje, Kelvin, Suzanne Filteau, Thomas Clasen, Rachel Peletz (132102), Filteau, S, Clasen Thomas, Paul Kelly, Martin Simunyama, Kathy Baisley (132119), Martin Simunyama (132107), Baisley, Kathy, Thomas Clasen (132131), Paul Kelly (95510), Simunyama, M, Peletz, Rachel, Clasen, T, Kathy Baisley, Filteau Suzanne, Filteau, Suzanne, Rachel Peletz, Kelvin Sarenje, Kelvin Sarenje (132113), Suzanne Filteau (132124), Peletz Rachel, Kelly Paul, Baisley Kathy, Baisley, K, Kelly, Paul, Sarenje, K, Kelly, P   +34 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source