Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. [PDF]
, 2018 OBJECTIVE:Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after ...
Chondronikola, Maria +7 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Systematic Review and the External Validity of Randomized Controlled Trials in Lupus Nephritis
Kidney International Reports, 2018 Randomized controlled trials (RCTs) are considered the gold standard for assessing treatment efficacy. However, sampling bias can affect the generalization of results to routine clinical practice.
Angela Pakozdi +4 more
doaj +1 more source
Zinc Supplementation during Pregnancy: A Randomized Controlled Trial [PDF]
Zinc deficiency during pregnancy has been related to adverse pregnancy outcomes. However, the results of zinc-supplementation trials have not been consistent in improvement of pregnancies outcomes.
امینی ثانی, نیره +5 more
core
Patients with Borderline Personality Disorder Not Participating in an RCT: Are They Different? [PDF]
, 2010 Background: Despite the notion that randomized controlled trials are regarded as the gold standard in psychotherapy research, questions about their generalizability have been raised. This paper focuses on the differences between participants and eligible
Buchheim, Peter +5 more
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Effectiveness of foot orthosis in patients with rheumatoid arthritis related to quality of life and pain. A systematic review and meta-analysis [PDF]
, 2017 Foot pain and deformity is almost ubiquitous in RA and results in considerable physical and psychosocial impairment. Epidemiological studies consistently suggest a 90% prevalence of foot pain despite advances in pharmacological therapy.
García-Mayor, Silvia +3 more
core
Stroke with unknown time of symptom onset: baseline clinical and magnetic resonance imaging data of the first thousand patients in WAKE-UP (efficacy and safety of mri-based thrombolysis in wake-up stroke: a randomized, doubleblind, placebo-controlled trial) [PDF]
, 2017 Background and Purpose—We describe clinical and magnetic resonance imaging (MRI) characteristics of stroke patients with unknown time of symptom onset potentially eligible for thrombolysis from a large prospective cohort.
Boutitie, Florent +18 more
core +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Randomized controlled trial of a smartphone app designed to reduce unhealthy alcohol consumption
Internet InterventionsBackground and aims: Unhealthy alcohol use is common and causes tremendous harm. Most people with unhealthy alcohol use will never seek formal alcohol treatment.
John A. Cunningham +6 more
doaj +1 more source