Results 101 to 110 of about 1,847,943 (315)

Web-based physiotherapy for people affected by multiple sclerosis: a single blind, randomized controlled feasibility study [PDF]

, 2018
Objective: To examine the feasibility of a trial to evaluate web-based physiotherapy compared to a standard home exercise programme in people with multiple sclerosis. Design: Multi-centre, randomized controlled, feasibility study.
Alex McConnachie, Belinda Weller, Berg K, Brazier J, Brennan DM, Cohen J., Curtis L, Elaine H Coulter, Frevel D, Heather Murray, Jennifer Freeman, Khan F, Linda Renfrew, Lorna Paul, Olivia Wu, Paul Mattison, Robert Heggie   +16 more
core   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Ketamine Trial for Acute Suicidality (KETA): Study Protocol of a Double‐Blind Randomized Placebo‐Controlled Superiority Trial on Intranasal Racemic Ketamine Compared to the Active Placebo Intranasal Midazolam as Treatment for Acute Suicidality

International Journal of Methods in Psychiatric Research
Background Suicidality is a transdiagnostic entity in patients with and without psychiatric disorders. Ketamine is a novel treatment for treatment‐resistant depression with favorable effects on related suicidality in this population.
Jurriaan F. M. Strous, Gijs H. J. Roelandt, Jens H. vanDalfsen, Jeanine Kamphuis, Radboud M. Marijnissen, Robert A. Schoevers   +5 more
doaj   +1 more source

Estimating vaccine efficacy during open-label follow-up of COVID-19 vaccine trials based on population-level surveillance data

Epidemics
While rapid development and roll out of COVID-19 vaccines is necessary in a pandemic, the process limits the ability of clinical trials to assess longer-term vaccine efficacy. We leveraged COVID-19 surveillance data in the U.S.
Mia Moore, Yifan Zhu, Ian Hirsch, Tom White, Robert C. Reiner, Ryan M. Barber, David Pigott, James K. Collins, Serena Santoni, Magdalena E. Sobieszczyk, Holly Janes   +10 more
doaj   +1 more source

Transfer of manualized CBT for social phobia into clinical practice (SOPHO-PRAX) : a study protocol for a cluster-randomized controlled trial [PDF]

, 2012
Background: Cognitive-behavioral therapy (CBT) is generally known to be efficacious in the treatment of social phobia when applied in RCT's, namely when the treatment manual is based on the Clark-Wells approach.
Crawcour, Stephen, Ginzburg, Denise, Hoyer, Jürgen, Leibing, Eric, Stangier, Ulrich, Wiltink, Jörg   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficacy of Two Doses of Ivermectin Tablet in Treatment of Scabies in Comparison to Once Application of 5% Permethrin Lotion – A Randomized Controlled Trial

Indian Journal of Community Medicine
Background: Scabies may cause community outbreaks without early diagnosis and appropriate treatment. Oral ivermectin offsets some of the challenges associated with topical 5% permethrin application for treating scabies.
Debkumar Pal, Priyamadhaba Behera, Mythry Ravichandran, Dinesh P. Sahu, Chandra S. Sirka, Binod K. Patro, Siddharth Dash, Manish Taywade   +7 more
doaj   +1 more source

Yoga for generalized anxiety disorder: design of a randomized controlled clinical trial. [PDF]

, 2015
Generalized anxiety disorder (GAD) is a common disorder associated with significant distress and interference. Although cognitive behavioral therapy (CBT) has been shown to be the most effective form of psychotherapy, few patients receive or have access ...
Bui, Eric, Curtiss, Joshua, Hofmann, Stefan G., Hoge, Elizabeth, Keshaviah, Aparna, Khalsa, Sat Bir S., Rosenfield, David, Simon, Naomi   +7 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source