Results 101 to 110 of about 4,272,652 (308)

Stroke with unknown time of symptom onset: baseline clinical and magnetic resonance imaging data of the first thousand patients in WAKE-UP (efficacy and safety of mri-based thrombolysis in wake-up stroke: a randomized, doubleblind, placebo-controlled trial) [PDF]

, 2017
Background and Purpose—We describe clinical and magnetic resonance imaging (MRI) characteristics of stroke patients with unknown time of symptom onset potentially eligible for thrombolysis from a large prospective cohort.
Boutitie, Florent, Cheng, Bastian, Cho, Tae-Hee, Ebinger, Martin, Endres, Matthias, Fiebach, Jochen B., Fiehler, Jens, Ford, Ian, Galinovic, Ivana, Gerloff, Christian, Lemmens, Robin, Muir, Keith W., Nighoghossian, Norbert, Pedraza, Salvador, Puig, Josep, Roy, Pascal, Simonsen, Claus Z., Thijs, Vincent, Thomalla, Götz   +18 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The Ketamine Trial for Acute Suicidality (KETA): Study Protocol of a Double‐Blind Randomized Placebo‐Controlled Superiority Trial on Intranasal Racemic Ketamine Compared to the Active Placebo Intranasal Midazolam as Treatment for Acute Suicidality

International Journal of Methods in Psychiatric Research
Background Suicidality is a transdiagnostic entity in patients with and without psychiatric disorders. Ketamine is a novel treatment for treatment‐resistant depression with favorable effects on related suicidality in this population.
Jurriaan F. M. Strous, Gijs H. J. Roelandt, Jens H. vanDalfsen, Jeanine Kamphuis, Radboud M. Marijnissen, Robert A. Schoevers   +5 more
doaj   +1 more source

Estimating vaccine efficacy during open-label follow-up of COVID-19 vaccine trials based on population-level surveillance data

Epidemics
While rapid development and roll out of COVID-19 vaccines is necessary in a pandemic, the process limits the ability of clinical trials to assess longer-term vaccine efficacy. We leveraged COVID-19 surveillance data in the U.S.
Mia Moore, Yifan Zhu, Ian Hirsch, Tom White, Robert C. Reiner, Ryan M. Barber, David Pigott, James K. Collins, Serena Santoni, Magdalena E. Sobieszczyk, Holly Janes   +10 more
doaj   +1 more source

Yoga for generalized anxiety disorder: design of a randomized controlled clinical trial. [PDF]

, 2015
Generalized anxiety disorder (GAD) is a common disorder associated with significant distress and interference. Although cognitive behavioral therapy (CBT) has been shown to be the most effective form of psychotherapy, few patients receive or have access ...
Bui, Eric, Curtiss, Joshua, Hofmann, Stefan G., Hoge, Elizabeth, Keshaviah, Aparna, Khalsa, Sat Bir S., Rosenfield, David, Simon, Naomi   +7 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Efficacy of Two Doses of Ivermectin Tablet in Treatment of Scabies in Comparison to Once Application of 5% Permethrin Lotion – A Randomized Controlled Trial

Indian Journal of Community Medicine
Background: Scabies may cause community outbreaks without early diagnosis and appropriate treatment. Oral ivermectin offsets some of the challenges associated with topical 5% permethrin application for treating scabies.
Debkumar Pal, Priyamadhaba Behera, Mythry Ravichandran, Dinesh P. Sahu, Chandra S. Sirka, Binod K. Patro, Siddharth Dash, Manish Taywade   +7 more
doaj   +1 more source

Effectiveness of foot orthosis in patients with rheumatoid arthritis related to quality of life and pain. A systematic review and meta-analysis [PDF]

, 2017
Foot pain and deformity is almost ubiquitous in RA and results in considerable physical and psychosocial impairment. Epidemiological studies consistently suggest a 90% prevalence of foot pain despite advances in pharmacological therapy.
García-Mayor, Silvia, Gijón-Noguerón, Gabriel, Morales-Asencio, Jose Miguel, Ramos-Petersen, Silvia   +3 more
core  

Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. [PDF]

, 2018
OBJECTIVE:Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after ...
Chondronikola, Maria, Klein, Samuel, Magkos, Faidon, Muehlbauer, Michael J, Newgard, Christopher B, Okunade, Adewole L, Patterson, Bruce W, Yoshino, Jun   +7 more
core   +1 more source

Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial

Trials, 2018
BackgroundIt had been more than 5 years since the first case of Middle East Respiratory Syndrome coronavirus infection (MERS-CoV) was recorded, but no specific treatment has been investigated in randomized clinical trials.
Y. Arabi, A. Alothman, H. Balkhy, A. Al-Dawood, Sameera M Aljohani, Shmeylan A. Al Harbi, S. Kojan, Majed Al Jeraisy, A. Deeb, Abdullah M. Assiri, F. Al-Hameed, A. Alsaedi, Y. Mandourah, G. Almekhlafi, N. M. Sherbeeni, F. Elzein, Javed Memon, Yusri Taha, Abdullah Almotairi, Khalid A. Maghrabi, I. Qushmaq, A. Al bshabshe, A. Kharaba, S. Shalhoub, J. Jose, Robert A. Fowler, F. Hayden, M. Hussein, Yaseen M. Adel Hanan H Abdulaziz Sameera Shmeylan Suleima Arabi Alothman Balkhy Al-Dawood AlJohani Al Harbi , Y. Arabi, A. Alothman, H. Balkhy, A. Al-Dawood, Sameera M Aljohani, Shmeylan A. Al Harbi, S. Kojan, Majed Al Jeraisy, A. Deeb, J. Jose, M. Hussein, Mohammed Al Muhaidib, M. Sadat, H. Al Anizi, Reggie Dael, Abdullah M. Assiri, Mohammad A. Almazroa, A. Asiri, Z. Memish, S. Ghazal, Sarah H. Alfaraj, Fahad Bafaqeeh, Abdulrahman Al Harthy, Mohammed Al Sulaiman, A. Mady, Y. Mandourah, G. Almekhlafi, N. M. Sherbeeni, F. Elzein, R. Muhammed, Shatha Al Samirrai, Shatha Awad, Rylen Cabio Cabal, A. Malibary, Bander Al Onazi, M. Aljuhani, Melven Vince, Abdullah Almotairi, Mushira Al Enani, Alaa Alqurashi, F. Alenezi, Nada M. Alkhani, Khalid A. Maghrabi, F. Al-Hameed, A. Alsaedi, A. Thaqafi, Ohoud Al Oraabi, Jalal Rifai, Pansy Elsamadisi, Medhat S. Hendy, S. Basher, Muhammed Abduldhaher, Wael Bajhamoum, I. Qushmaq, S. Shalhoub, Yusri Taha, Javed Memon, Shahinaz Bashir, I. Al-Dossary, Saleh Al Mekhloof, Bader Al-Muhainy, S. Suliman, M. Alshahrani, A. Al bshabshe, A. Kharaba, A. Al Jabri, Magdy F Farid, Alawi Alaidarous, Wael Alseraihi, H. Shahada, Jinish Shimi, S. Riaz, Bader Alharthi, Osama Yasin, Mohammad Khathlan, Robert A. Fowler, F. Hayden   +105 more
semanticscholar   +1 more source