Results 81 to 90 of about 4,375,535 (213)

Internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole: a pragmatic randomized controlled trial [PDF]

, 2011
<p>Purpose: To determine whether internal limiting membrane (ILM) peeling is effective and cost effective compared with no peeling in patients with idiopathic stage 2 or 3 full-thickness maculay hole (FTMH).</p> <p>Methods: This was ...
Cook, Jonathan, Vale, L., Vale, Luke, Noemi Lois, Ternent, L., Full-thickness Macular Hole and Internal Limiting Membrane Peeling Study (FILMS) Group, McDonald, A, Cook, J, Full-Thickness Macular Hole, McPherson, G., McPherson, Gladys, Jennifer Burr, Burr, J., McDonald, A., Lois, N., Cook, J., McDonald, Alison, John Norrie, Boachie, Charles, Vale, L, Burr, Jennifer Margaret, Alison McDonald, Lois, N, Gladys McPherson, Laura Ternent, Charles Boachie, Ternent, L, McPherson, G, Ternent, Laura, Norrie, J, Luke Vale, Norrie, J., Boachie, C., Lois, Noemi, Burr, J, Boachie, C, Norrie, John, Jonathan Cook   +37 more
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Evaluation of the effectiveness and cost-effectiveness of Families for Health V2 for the treatment of childhood obesity : study protocol for a randomized controlled trial [PDF]

, 2013
Background: Effective programs to help children manage their weight are required. Families for Health focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family.
Petrou, Stavros, Reddington, Kate, Simkiss, D, Thorogood, Margaret, Stallard, Nigel, Lang, R, Kirby, J. (Joanna), Stallard, N, Hamborg, T, Poole, Francine, Rye, G. (Gloria), Khan, Kamran, Griffiths, F, Thorogood, M, Reddington, K, Khan, KA, Stewart-Brown, Sarah L., Petrou, S, Kirby, J, Robertson, W, Lang, R. (Rebecca), Rye, G, Robertson, Wendy, Stewart-Brown, S, Poole, F, Simkiss, Douglas E., Griffiths, Frances, Hamborg, Thomas   +27 more
core   +1 more source

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

, 2012
Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Berger Michael, Dittmann, Sandra, Riedel Michael, Sophia, Frangou, Emanuel Severus, Bauer Michael, Severus, Emanuel, Pfennig Andrea, Florian Seemüller, Sophia Frangou, Michael, Bauer, Michael Bauer, Michael Riedel, Berger, Michael, Michael, Obermeier, Andrea, Pfennig, Michael Obermeier, Obermeier Michael, Seemüller Florian, Andrea Pfennig, Michael Berger, Hans-Jürgen, Möller, Dittmann Sandra, Michael, Riedel, Severus Emanuel, Frangou Sophia, Seemüller, Florian, Möller Hans-Jürgen, Sandra Dittmann, Hans-Jürgen Möller   +29 more
core   +2 more sources

The penumbra of randomized control trials

Perspectives in Clinical Research, 2013
Pre-occupation with randomized control trials as the basis of evidence-based medicine has increasingly shadowed other study designs over the last half a century. These include surveys, case-control studies, and case-cohort studies. They have the potential to overcome several ethical and cost constraints, but depend on the embedding of research in ...
openaire   +3 more sources

Effect of a governmentally-led physical activity program on motor skills in young children attending child care centers: a cluster randomized controlled trial [PDF]

, 2013
OBJECTIVE: To assess the effect of a governmentally-led center based child care physical activity program (Youp'la Bouge) on child motor skills.Patients and methods: We conducted a single blinded cluster randomized controlled trial in 58 Swiss child care
Jérôme Barral, Puder, Jardena J, Tanja H Kakebeeke, Longchamp, A., Kriemler, Susi, Christian Schindler, Bonvin, A., Jardena J Puder, Puder, J.J., Anouk Longchamp, Barral, J., Marques-Vidal, Pedro, Marques-Vidal, P., Pedro Marques-Vidal, Longchamp, Anouk, Kakebeeke, Tanja H., Kakebeeke, T.H., Kriemler, S., Puder, Jardena J., Kakebeeke, Tanja H; https://orcid.org/, Barral, Jérôme, Susi Kriemler, Schindler, Christian, Antoine Bonvin, Schindler, C., Bonvin, Antoine   +25 more
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Pitfalls of Randomized Controlled Trials in Stroke: How Can We Do Better?

Stroke: Vascular and Interventional Neurology, 2023
Shadi Yaghi, James E. Siegler, Thanh N. Nguyen   +2 more
doaj   +1 more source

Efficacy of Two Doses of Ivermectin Tablet in Treatment of Scabies in Comparison to Once Application of 5% Permethrin Lotion – A Randomized Controlled Trial

Indian Journal of Community Medicine
Background: Scabies may cause community outbreaks without early diagnosis and appropriate treatment. Oral ivermectin offsets some of the challenges associated with topical 5% permethrin application for treating scabies.
Debkumar Pal, Priyamadhaba Behera, Mythry Ravichandran, Dinesh P. Sahu, Chandra S. Sirka, Binod K. Patro, Siddharth Dash, Manish Taywade   +7 more
doaj   +1 more source

The effects of reducing worry in patients with persecutory delusions: study protocol for a randomized controlled trial [PDF]

, 2012
BACKGROUND: Our approach to advancing the treatment of psychosis is to focus on key single symptoms and develop interventions that target the mechanisms that maintain them.
Dunn, Graham, Kingdon David, Helen Startup, David Kingdon, Freeman, D, Daniel Freeman, Startup Helen, Kingdon, D, Dunn, G, Freeman Daniel, Dunn Graham, Kingdon, David, Freeman, Daniel, Startup, Helen, Startup, H, Graham Dunn   +15 more
core   +2 more sources

Randomized phase II study comparing two doses of regorafenib in second-line treatment for advanced hepatocellular carcinoma

JHEP Reports
Background & Aims: The RESORCE trial confirmed regorafenib as a second-line treatment for advanced hepatocellular carcinoma (HCC) in patients who tolerated sorafenib.
Keisuke Koroki, Sadahisa Ogasawara, Sae Yumita, Miyuki Nakagawa, Hiroaki Kanzaki, Kazufumi Kobayashi, Masanori Inoue, Masato Nakamura, Naoya Kanogawa, Takayuki Kondo, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Yuki Shiko, Yoshihito Ozawa, Yosuke Inaba   +15 more
doaj   +1 more source

Primary care practice-based care management for chronically ill patients (PraCMan): study protocol for a cluster randomized controlled trial [ISRCTN56104508] [PDF]

, 2011
Background: Care management programmes are an effective approach to care for high risk patients with complex care needs resulting from multiple co-occurring medical and non-medical conditions.
Baldauf Annika, Gerlach, Ferdinand M., Joachim Szecsenyi, Beyer Martin, Szecsenyi, Joachim, Gerlach Ferdinand M, Peters-Klimm Frank, Ferdinand M Gerlach, Peters-Klimm, Frank, Erler, Antje, Cornelia Mahler, Rochon Justine, Gensichen Jochen, Mahler Cornelia, Freund, Tobias, Martin Beyer, Antje Erler, Szecsenyi Joachim, Gensichen, Jochen, Freund Tobias, Beyer, Martin, Justine Rochon, Mahler, Cornelia, Baldauf, Annika, Tobias Freund, Frank Peters-Klimm, Jochen Gensichen, Rochon, Justine, Erler Antje, Annika Baldauf   +29 more
core   +2 more sources