Results 71 to 80 of about 1,017,967 (316)

The penumbra of randomized control trials

Perspectives in Clinical Research, 2013
Pre-occupation with randomized control trials as the basis of evidence-based medicine has increasingly shadowed other study designs over the last half a century. These include surveys, case-control studies, and case-cohort studies. They have the potential to overcome several ethical and cost constraints, but depend on the embedding of research in ...
openaire   +3 more sources

Animal‐Assisted Activities With Therapy Dogs in Pediatric Oncology: A Multicenter Survey of the Current Status, Implementation, and Challenges in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Animal‐assisted activities (AAAs) with therapy dogs have shown positive effects on patient well‐being and quality of life in various areas of medicine, including pediatric oncology. However, research on this topic is limited. The aim of this study is to present the current status of AAA in pediatric oncology in Germany, Austria, and
Jan‐Marius Wedig, Birgit Burkhardt, Christof M. Kramm, Kira Ostermann, Sarah C. Goretzki, Uta Dirksen, Nico Kurpiers, Michael M. Schündeln   +7 more
wiley   +1 more source

Weight management for overweight and obese men delivered through professional football clubs: a pilot randomized trial [PDF]

, 2013
Background: The prevalence of male obesity is increasing, but men are less likely than women to attend existing weight management programmes. We have taken a novel approach to reducing perceived barriers to weight loss for men by using professional ...
Shaun Treweek, Gray, Cindy M., Mutrie, N., Cindy M Gray, Gray, C.M., Hunt, Kate, Anderson, Annie S., Hunt, K., Mutrie, Nanette, Sally Wyke, Gray, Cindy M, Annie S Anderson, Wyke, Sally, Wyke, S., Treweek, S., Anderson, Annie S, Nanette Mutrie, Anderson, Annie S.; id_orcid, Kate Hunt, Treweek, Shaun, Anderson, A.S.   +20 more
core   +1 more source

Electroacupuncture treatment for sarcopenia: study protocol for a randomized controlled trial

BMC Complementary Medicine and Therapies
Introduction Sarcopenia is a disease primarily characterized by age-related loss of skeletal muscle mass, muscle strength, and/or decline in physical performance.
Hao Li, Li Zhou, Xin Zhang, Qian Wen, Li Tian, Han Yang, Xirong Chen, Jinghan Yuan, Ning Li, Bingmei Zhu, Lin Zhang, Lingyun Lu   +11 more
doaj   +1 more source

Cluster‐randomized controlled trials: A tutorial

Cochrane Evidence Synthesis and Methods, 2023
This tutorial focuses on cluster-randomised controlled trials. We will explain what cluster-RCTs are, why they might be used, and how to include data from cluster-randomised controlled trials in systematic reviews. Accompanying the tutorial is a micro-learning module, which will give you the chance to practice adjusting data from cluster-randomised ...
Marty Chaplin, Kerry Dwan
openaire   +3 more sources

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Systematic techniques for assisting recruitment to trials (START): study protocol for embedded, randomized controlled trials [PDF]

, 2014
Background Randomized controlled trials play a central role in evidence-based practice, but recruitment of participants, and retention of them once in the trial, is challenging.
Anne Kennedy, Shaun Treweek, Madurasinghe, Vichithranie, Wallace, P, David J. Collier, Paul Wallace, Kennedy, A, Bower, P; id_orcid, Peter Knapp, Treweek, S, Small, N; id_orcid, Bower, P, Eldridge, Sandra, Graffy, Jonathan, Graffy, J, David Torgerson, Wallace, Paul, Knapp, P, Nicola Small, Hughes-Morley, A, Salisbury, Chris, Treweek, Shaun, Eldridge, S, Chris Salisbury, Small, N, Torgerson, D, Peter Bower, Bower, Peter, Hughes-Morley, Adwoa, Madurasinghe, V, Knapp, Peter, Torgerson, David, Rick, J, Adwoa Hughes-Morley, Rick, Jo, Salisbury, C, Kennedy, Anne, Collier, DJ, Jonathan Graffy, Vichithranie Madurasinghe, Jo Rick, Collier, David J, Small, Nicola, Sandra Eldridge   +43 more
core   +1 more source

The importance of clinical trial protocols

HSJ
The International Committee of Medical Journal Editors (ICMJE) and the World Health Organization (WHO) define a clinical trial as any research that prospectively assigns participants or groups of human subjects to one or more interventions (medicines ...
Melissa Andreia de Moraes Silva
doaj   +1 more source

Effects of photobiomodulation on re-epithelialization of burn wound: protocol for a randomized controlled trial

Trials, 2022
Background Burns are a global public health problem and cause approximately 180,000 deaths annually, mainly in low- and middle-income countries. Topical antibiotics and occlusive dressing are standard treatments for burns not requiring a skin graft ...
Silvana Cristina de Araújo Pereira Venceslau, Júlia Lacet Silva Ferreira, Renata Maria Freire Barros, Ronny Marcos de Morais, Heleodório Honorato dos Santos, Valéria Mayaly Alves de Oliveira, Palloma Rodrigues de Andrade   +6 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source