Results 51 to 60 of about 1,847,943 (315)

Registry or randomization – must it be evidence or could it be coincidence?

Innovative Surgical Sciences
Over the years, clinical registries and randomized controlled trials gained acceptance. With increasing experience, it was possible to obtain knowledge of benefits and limitations in both designs.
Radulova Olga, Oehme Florian, Korn Sandra, Praetorius Christian, Distler Marius, Weitz Jürgen   +5 more
doaj   +1 more source

Evaluation of Randomized Controlled Trials [PDF]

Circulation, 2007
Although randomized controlled trials (RCTs) play a key role in modern medicine, considerable variability exists in their quality and in the reliability (reproducibility) of their results. The present article discusses features that characterize high-quality trials, such as intent-to-treat (ITT) analysis, the avoidance of patient exclusions, and a ...
openaire   +2 more sources

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Evaluating the Feasibility of Using Historical Placebo Control in Osteoarthritis Trials

Epidemiologia
Background/Objectives: Randomized controlled trials (RCTs) are the gold standard for evaluating treatment efficacy, yet recruitment and retention remain challenging, particularly when placebo arms are required.
Justine Monseur, Emma Barbeau, Anne-Françoise Donneau, Olivier Bruyère   +3 more
doaj   +1 more source

Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial [PDF]

, 2013
Objective: To assess the feasibility of conducting a randomized controlled trial of occupational therapy predischarge home visits for people after stroke. Design: Randomized controlled trial and cohort study.
Drummond, A.E.R., Edwards, Claire, Fellows, K., Lincoln, Nadina, Sampson, Christopher James, Sprigg, Nikola, Whitehead, P.   +6 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The importance of clinical trial protocols

HSJ
The International Committee of Medical Journal Editors (ICMJE) and the World Health Organization (WHO) define a clinical trial as any research that prospectively assigns participants or groups of human subjects to one or more interventions (medicines ...
Melissa Andreia de Moraes Silva
doaj   +1 more source

Antiplaque efficacy of toothpaste – A systematic review and meta-analysis of randomized controlled trials

Journal of Indian Association of Public Health Dentistry, 2022
Background: Different toothpastes of the corresponding active ingredients could have variable extent of effectiveness; this raises the amount of choices with the marketplace for toothpaste containing these agents and makes it more difficult to gauge ...
Sneha Nachu, Srinivas Ravoori, Srinivas Pachava   +2 more
doaj   +1 more source

Noninvasive vagus nerve stimulation as acute therapy for migraine. The randomized PRESTO study [PDF]

, 2018
Objective: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled ...
Ambrosini, Anna, Barbanti, Piero, De Tommaso, Marina, Dorlas, Stefanie, Geppetti, Pierangelo, Grazzi, Licia, Liebler, Eric, Martelletti, Paolo, Negro, Andrea, Pierangeli, Giulia, Rainero, Innocenzo, Sarchielli, Paola, Tassorelli, Cristina   +12 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source