Results 31 to 40 of about 4,375,535 (213)

The external validity of published randomized controlled trials in primary care [PDF]

, 2009
Background - A criticism of Randomized Controlled Trials (RCTs) in primary care is that they lack external validity, participants being unrepresentative of the wider population.
Jones Robert O, McCowan, Colin, Jones, R, Colin McCowan (434192), McCowan, C, Fahey, T., Jones, Robert O., Colin McCowan, Montgomery, AA, Fahey Tom, Jones, RO, Fahey, T, McCowan Colin, Alan A Montgomery, Montgomery Alan A, Jones Ritu, Fahey, Thomas, Robert O Jones, Ritu Jones (7944167), Tom Fahey (7896266), Robert O. Jones (7944170), Alan A. Montgomery (7705694), Tom Fahey, Ritu Jones, Mccowan, C., Montgomery, A.A., Jones, R.O., Montgomery, Alan A., Jones, R., Jones, Ritu   +29 more
core   +2 more sources

Malaria positivity following a single oral dose of azithromycin among children in Burkina Faso: a randomized controlled trial

BMC Infectious Diseases, 2022
Background Azithromycin is a broad-spectrum antibiotic that has moderate antimalarial activity and has been shown to reduce all-cause mortality when biannually administered to children under five in high mortality settings in sub-Saharan Africa.
Jessica Brogdon, Clarisse Dah, Ali Sié, Mamadou Bountogo, Boubacar Coulibaly, Idrissa Kouanda, Mamadou Ouattara, Guillaume Compaoré, Eric Nebie, Mariam Seynou, Elodie Lebas, Fanice Nyatigo, Huiyu Hu, Benjamin F. Arnold, Thomas M. Lietman, Catherine E. Oldenburg   +15 more
doaj   +1 more source

Effect of head and facial massage combined with aromatherapy on sleep quality and delirium in patients with acute myocardial infarction: A randomized controlled trial

Complementary Therapies in Medicine
Background: Delirium and sleep disturbances are common among patients with acute myocardial infarction (AMI) admitted to the Cardiac Intensive Care Unit (CCU), often leading to increased mortality and prolonged hospitalization.
Mehrnaz Kharatha, Somayeh Rezaie, Seyedeh Solmaz Talebi, Hossein Ebrahimi   +3 more
doaj   +1 more source

Dermatology and Randomized Control Trials

Indian Dermatology Online Journal, 2021
Well-designed and rigorously conducted randomized controlled trial (RCT) can produce most valid and precise scientific evidence. Any intervention, be it systemic or topical medicine, dermatology procedure needs to be tested for its efficacy in improving particular disease condition and RCT should come into mind of investigator.
Patel, Nayankumar, Sil, Amrita
openaire   +2 more sources

Intraoperative and postoperative clinical evaluation of the hysteroscopic morcellator system for endometrial polypectomy: A prospective, randomized, single-blind, parallel group comparison study

Gynecology and Minimally Invasive Therapy, 2018
Objective: To evaluate the TRUCLEAR™ system (Smith and Nephew Inc., London, UK), a hysteroscopic system that morcellates and aspirates masses, in terms of the operating time, surgeon's convenience, and effect on patients compared with conventional ...
Akira Tsuchiya, Yasunori Komatsu, Reiko Matsuyama, Hiroko Tsuchiya, Yuri Takemura, Osamu Nishii   +5 more
doaj   +1 more source

Lenalidomide in cancer cachexia: a randomized trial of an anticancer drug applied for anti‐cachexia

JCSM Rapid Communications, 2022
Background Cancer cachexia (CC) impacts quality of life, physical function, anticancer treatment response, and survival. Inflammation is a prominent pathomechanism of CC.
David Blum, Caroline Hertler, Rolf Oberholzer, Susanne deWolf‐Linder, Markus Joerger, Christoph Driessen, Florian Strasser   +6 more
doaj   +1 more source

Interpreting Randomized Controlled Trials

Cancers, 2023
This article describes rationales and limitations for making inferences based on data from randomized controlled trials (RCTs). We argue that obtaining a representative random sample from a patient population is impossible for a clinical trial because patients are accrued sequentially over time and thus comprise a convenience sample, subject only to ...
Pavlos Msaouel, Juhee Lee, Peter F Thall
openaire   +2 more sources

Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D3 and/or calcium (RECORD Trial) [PDF]

, 2012
Context: Vitamin D or calcium supplementation may have effects on vascular disease and cancer. Objective: Our objective was to investigate whether vitamin D or calcium supplementation affects mortality, vascular disease, and cancer in older people ...
McDonald, AM, Campbell, MK, Torgerson, DJ, Marsh, D., RECORD Trial Group, Pant, Puspa R., Grant, Adrian, Adrian M. Grant, Wallace, W Angus., Wallace, W. Angus, MacLennan, GS, Eastell, R., Campbell, Marion K., Robinson, C. Michael, Cyrus Cooper, David J. Torgerson, Maclennan, Graeme S., Wallace, WA, McPherson, GC, Avenell, A, null null, Grant, AM, Francis, Roger M., Graeme S. MacLennan, William J. Gillespie, Jenkinson, David, Khaw, K. T., Francis, RM, McDonald, GM, Pant, PR, C. Michael Robinson, Cooper, Cyrus, Alison M. McDonald, Roger M. Francis, Jenkinson, DJ, McDonald, Alison M., Jenkinson, David J., Frazer H. Anderson, W. Angus Wallace, Torgerson, David J., David J. Jenkinson, Robinson, CM, Puspa R. Pant, Grant, Adrian M., Anderson, FH, Marion K. Campbell, Pant, Puspa Raj, Anderson, Frazer H., Alison Avenell, Cooper, C, Avenell, Alison, McPherson, Gladys C., Gillespie, William J., Gladys C. McPherson, Gillespie, WJ   +54 more
core   +1 more source

Der erste Schritt in eine neue Ära?

Monitor Versorgungsforschung
Glückwunsch dem Stifter und allen Gewinnern des MSD Gesundheitspreises 2025. Jedes der Teams hat eine wertvolle Idee präsentiert. Jetzt gilt es, diese Ideen auch in Lösungen umzusetzen.
Prof. Dr. Franz Porzsolt
doaj   +1 more source

Alternatives to the Randomized Controlled Trial

American Journal of Public Health, 2008
Public health researchers are addressing new research questions (e.g., effects of environmental tobacco smoke, Hurricane Katrina) for which the randomized controlled trial (RCT) may not be a feasible option. Drawing on the potential outcomes framework (Rubin Causal Model) and Campbellian perspectives, we consider alternative research ...
Stephen G, West, Naihua, Duan, Willo, Pequegnat, Paul, Gaist, Don C, Des Jarlais, David, Holtgrave, José, Szapocznik, Martin, Fishbein, Bruce, Rapkin, Michael, Clatts, Patricia Dolan, Mullen   +10 more
openaire   +3 more sources