Results 31 to 40 of about 1,847,943 (315)

Lenalidomide in cancer cachexia: a randomized trial of an anticancer drug applied for anti‐cachexia

JCSM Rapid Communications, 2022
Background Cancer cachexia (CC) impacts quality of life, physical function, anticancer treatment response, and survival. Inflammation is a prominent pathomechanism of CC.
David Blum, Caroline Hertler, Rolf Oberholzer, Susanne deWolf‐Linder, Markus Joerger, Christoph Driessen, Florian Strasser   +6 more
doaj   +1 more source

Lee Silverman voice treatment versus standard NHS speech and language therapy versus control in Parkinson's disease (PD COMM pilot):study protocol for a randomized controlled trial [PDF]

, 2014
Background: Parkinson’s disease is a common movement disorder affecting approximately 127,000 people in the UK, with an estimated two thirds having speech-related problems.
Brady, Marian C, Clarke, Carl, Dowling, Francis, Ives, Natalie, Jowett, Sue, Kelly, Debbie, Patel, Ramilla, Patel, Smitaa, Rick, Caroline, Roberts, Helen, Sackley, Catherine M, Sands, Gina, Smith, Christina H, Wheatley, Keith   +13 more
core   +4 more sources

Bias and Sensitivity Analysis When Estimating Treatment Effects from the Cox Model with Omitted Covariates [PDF]

, 2013
Omission of relevant covariates can lead to bias when estimating treatment or exposure effects from survival data in both randomized controlled trials and observational studies. This paper presents a general approach to assessing bias when covariates are
Henley, William Edward, Lin, Nan, Logan, Stuart   +2 more
core   +2 more sources

Alternatives to the Randomized Controlled Trial

American Journal of Public Health, 2008
Public health researchers are addressing new research questions (e.g., effects of environmental tobacco smoke, Hurricane Katrina) for which the randomized controlled trial (RCT) may not be a feasible option. Drawing on the potential outcomes framework (Rubin Causal Model) and Campbellian perspectives, we consider alternative research ...
Stephen G, West, Naihua, Duan, Willo, Pequegnat, Paul, Gaist, Don C, Des Jarlais, David, Holtgrave, José, Szapocznik, Martin, Fishbein, Bruce, Rapkin, Michael, Clatts, Patricia Dolan, Mullen   +10 more
openaire   +3 more sources

Analysis of Randomized Controlled Trials [PDF]

Epidemiologic Reviews, 2002
Although the sophistication and flexibility of the statistical technology available to the data analyst have increased, some durable, simple principles remain valid. Hypothesis-driven analyses, which were anticipated and specified in the protocol, must still be kept separate and privileged relative to the important, but risky data mining made possible ...
Peter, Peduzzi, William, Henderson, Pamela, Hartigan, Philip, Lavori   +3 more
openaire   +2 more sources

Der erste Schritt in eine neue Ära?

Monitor Versorgungsforschung
Glückwunsch dem Stifter und allen Gewinnern des MSD Gesundheitspreises 2025. Jedes der Teams hat eine wertvolle Idee präsentiert. Jetzt gilt es, diese Ideen auch in Lösungen umzusetzen.
Prof. Dr. Franz Porzsolt
doaj   +1 more source

Oral labetalol compared to oral nifedipine for postpartum hypertension: A randomized controlled trial

Hypertension in Pregnancy, 2017
Objective: To determine whether oral labetalol is associated with a shorter time to blood pressure control compared to oral extended release nifedipine for management of persistent postpartum hypertension.
Kathryn J. Sharma, Naomi Greene, Sarah J. Kilpatrick   +2 more
doaj   +1 more source

Comparison between epley and gans repositioning maneuvers for posterior canal BPPV: A randomized controlled trial

Annals of Indian Academy of Neurology, 2023
Objectives: Benign paroxysmal positional vertigo (BPPV) is a condition in which a patient gets severe vertigo on moving his head from one position to another.
Neetu R Dhiman, Deepika Joshi, Vyom Gyanpuri, Abhishek Pathak, Anand Kumar   +4 more
doaj   +1 more source

Web-Based Randomized Controlled Trial [PDF]

, 2017
Background: Patients often seek other patients’ experiences with the disease. The Internet provides a wide range of opportunities to share and learn about other people’s health and illness experiences via blogs or patient-initiated online discussion ...
Giesler, Jürgen M., Holmberg, Christine, Keller, Bettina, Leonhart, Rainer, Lucius-Hoene, Gabriele, Muckelbauer, Rebecca, Müller-Nordhorn, Jacqueline, Repke, Tim, Rieckmann, Nina, Weis, Joachim   +9 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source