Results 61 to 70 of about 1,017,967 (316)

Evaluating the Feasibility of Using Historical Placebo Control in Osteoarthritis Trials

Epidemiologia
Background/Objectives: Randomized controlled trials (RCTs) are the gold standard for evaluating treatment efficacy, yet recruitment and retention remain challenging, particularly when placebo arms are required.
Justine Monseur, Emma Barbeau, Anne-Françoise Donneau, Olivier Bruyère   +3 more
doaj   +1 more source

The Effects of Cognitive Behavioral Therapy on Depression and Anxiety among Patients with Thalassemia: a Randomized Controlled Trial [PDF]

Journal of Caring Sciences, 2018
Introduction: Thalassemia is a chronic hereditary anemia which can be associated with different psychological, emotional, and behavioral problems such as depression and anxiety.
Fateme Mohamadian, Maryam Bagheri, Maryam Sadat Hashemi, Hossein Komeili Sani   +3 more
doaj   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Brief intervention to reduce risky drinking in pregnancy: study protocol for a randomized controlled trial [PDF]

, 2012
Background Risky drinking in pregnancy by UK women is likely to result in many alcohol-exposed pregnancies. Studies from the USA suggest that brief intervention has promise for alcohol risk reduction in antenatal care. However, further research is needed
Hodgson Moira, Antony, Grace, McGovern Ruth, Rankin Judith, Mark Deverill, Kirsty Laing, Wilson, Graeme B, Gilvarry Eilish, Rankin, Judith, Kaner Eileen FS, Newbury-Birch, Dorothy, Newbury-birch, Dorothy; id_orcid, Kaner, Eileen Fs, Laing Kirsty, Wilson Graeme B, Antony Grace, McColl Elaine, Erin Graybill, Deverill Mark, Cassidy, Paul, Hodgson, Moira, Dorothy Newbury-Birch, Gilvarry, Eilish, McColl, Elaine, Graybill Erin, Cassidy Paul, McGovern, Ruth, Laing, Kirsty, Graeme B Wilson, Judith Rankin, Grace Antony, Newbury-Birch Dorothy, Deverill, Mark, Eilish Gilvarry, Paul Cassidy, Graybill, Erin, Kaner, Eileen F. S., Elaine McColl, Eileen FS Kaner, Wilson, Graeme B., Ruth McGovern, Moira Hodgson   +41 more
core   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

Cluster randomized trial in the general practice research database: 2. Secondary prevention after first stroke (eCRT study): study protocol for a randomized controlled trial. [PDF]

, 2012
BACKGROUND: The purpose of this research is to develop and evaluate methods for conducting pragmatic cluster randomized trials in a primary care electronic database.
Wolfe Charles, Van Staa, Tjeerd; id_orcid, van Staa, Tjeerd, Mcdermott Lisa, Judith Charlton, Gulliford, Martin, Gerard McCann, Charlton, Judith, Ashworth Mark, Ashworth, Mark, Dregan Alex, McCann, Gerard, Charlton Judith, Anthony Rudd, Rudd Anthony, Lucy Yardley, Mark Ashworth, Gulliford Martin, Dregan, Alex; id_orcid, McCann Gerard, Lisa Mcdermott, Martin Gulliford, Tjeerd van Staa, Dregan, Alex, Yardley, Lucy, ?, ?, McDermott, Lisa, van Staa Tjeerd, null null, Wolfe, Charles, Yardley Lucy, Rudd, Anthony, eCRT Research Team, Charles Wolfe, Alex Dregan   +34 more
core   +1 more source

Promoting Independence in Dementia (PRIDE): A Feasibility Randomized Controlled Trial

Clinical Interventions in Aging, 2021
Emese Csipke,1 Aisha Shafayat,2 Kirsty Sprange,2 Lucy Bradshaw,2 Alan A Montgomery,2 Reuben Ogollah,2 Esme Moniz-Cook,3 Martin Orrell4 1Division of Psychiatry, University College London, London, UK; 2Nottingham Clinical Trials Unit, University of ...
Csipke E, Shafayat A, Sprange K, Bradshaw L, Montgomery AA, Ogollah R, Moniz-Cook E, Orrell M   +7 more
doaj  

Randomized clinical trials in ANCA-associated vasculitis: a systematic analysis of the WHO - International Clinical Trials Registry Platform

Orphanet Journal of Rare Diseases, 2020
Background The analysis of the main features of randomized controlled trials (RCTs) on ANCA-associated vasculitis (AAV) can inform future study design. Methods We searched within the International Clinical Trials Registry Platform all registered RCTs on ...
Michele Iudici, Xavier Puéchal, Alejandro Brigante, Ignacio Atal, Cem Gabay   +4 more
doaj   +1 more source

Development and Implementation of a Disease‐Targeted Storybook as a Clinical Tool for Children With Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Although significant progress has been made in childhood leukemia survival, healthcare providers, and caregivers often face challenges in explaining this disease to patients. Disease‐targeted storybooks have been proposed as a tool to facilitate the understanding of diagnoses and treatment.
Nutvipha Ummartyotin, Usanarat Anurathapan, Rawiwan Roongpraiwan, Potchanee Dandamrongrak, Siriporn Nakhonchai, Pawin Numthavaj, Vilawan Chirdkiatgumchai   +6 more
wiley   +1 more source

Aromatherapy Massage for Breast Cancer Patients: A Randomized Controlled Trial [PDF]

, 2018
The aim of this large randomized controlled study was to test the value of Aromatherapy (AM) with breast cancer patients for reducing symptoms, such as pain, anxiety, depression, emotional responses, insomnia, nausea/vomiting and the ability to cope ...
Anne Clemo-Crosby, Jenny Day Claire Stidston Shannon McGinley Roy John Powell
core   +1 more source