Results 61 to 70 of about 4,272,652 (308)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Effect of high-definition transcranial direct current stimulation among late-subacute and chronic stroke survivors with fatigue: A randomized-controlled crossover trial protocol

MethodsX
Post-stroke fatigue (PSF) is a commonly overlooked symptom that impacts daily functioning and quality of life. It is caused by altered functional connectivity within the brain networks, which can potentially be influenced by neuromodulation.
Akhila Jagadish, Manikandan Natarajan, Divya Bharatkumar Adhia, Annapoorna Kuppuswamy, Vasudeva Guddattu, John M. Solomon   +5 more
doaj   +1 more source

Promoting Independence in Dementia (PRIDE): A Feasibility Randomized Controlled Trial

Clinical Interventions in Aging, 2021
Emese Csipke,1 Aisha Shafayat,2 Kirsty Sprange,2 Lucy Bradshaw,2 Alan A Montgomery,2 Reuben Ogollah,2 Esme Moniz-Cook,3 Martin Orrell4 1Division of Psychiatry, University College London, London, UK; 2Nottingham Clinical Trials Unit, University of ...
Csipke E, Shafayat A, Sprange K, Bradshaw L, Montgomery AA, Ogollah R, Moniz-Cook E, Orrell M   +7 more
doaj  

Using Psychological Artificial Intelligence (Tess) to Relieve Symptoms of Depression and Anxiety: Randomized Controlled Trial

JMIR Mental Health, 2018
Background Students in need of mental health care face many barriers including cost, location, availability, and stigma. Studies show that computer-assisted therapy and 1 conversational chatbot delivering cognitive behavioral therapy (CBT) offer a less ...
Russell Fulmer, Angela Joerin, B. Gentile, Lysanne Lakerink, Michiel Rauws   +4 more
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Electroacupuncture treatment for sarcopenia: study protocol for a randomized controlled trial

BMC Complementary Medicine and Therapies
Introduction Sarcopenia is a disease primarily characterized by age-related loss of skeletal muscle mass, muscle strength, and/or decline in physical performance.
Hao Li, Li Zhou, Xin Zhang, Qian Wen, Li Tian, Han Yang, Xirong Chen, Jinghan Yuan, Ning Li, Bingmei Zhu, Lin Zhang, Lingyun Lu   +11 more
doaj   +1 more source

A randomized controlled trial on the effect of focal thermal therapy at acupressure points treating osteoarthritis of the knee

Journal of Orthopaedic Surgery and Research, 2021
Background Osteoarthritis of the knee is a common degenerative joint disorder in our ageing population. A combination of thermal therapy with a self-management exercise have shown a positive effect in the management of osteoarthritis of the knee.
Kevin Ki-Wai Ho, Anthony Wai-Leung Kwok, Wai-Wang Chau, S. M. Xia, Y. L. Wang, Jack Chun-Yiu Cheng   +5 more
doaj   +1 more source

What is the best way to manage benign paroxysmal positional vertigo? [PDF]

, 2003
A simple repositioning maneuver, such as the Epley maneuver, performed by an experienced clinician, can provide symptom relief from benign paroxysmal positional vertigo (BPPV) lasting at least 1 month (strength of recommendation [SOR]: A, systematic ...
Russell, Roger G., Strickland, Carmen
core  

From wealth to health: evaluating microfinance as a complex intervention [PDF]

, 2017
Innovative interventions that address the social determinants of health are required to help reduce persistent health inequalities. We argue that microcredit can act in this way and develop a conceptual framework from which to examine this.
Biosca , Olga, Donaldson, Cam, McHugh, Neil   +2 more
core   +1 more source