Results 121 to 130 of about 4,272,652 (308)

A randomized, placebo‐controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

Hepatology, 2018
The aim of this study was to evaluate cenicriviroc (CVC), a dual antagonist of CC chemokine receptor types 2 and 5, for treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis (LF).
S. Friedman, V. Ratziu, S. Harrison, M. Abdelmalek, G. Aithal, J. Caballería, S. Francque, G. Farrell, K. Kowdley, A. Craxì, K. Simon, L. Fischer, Liza Melchor-Khan, Jeffrey D. Vest, B. Wiens, P. Vig, S. Seyedkazemi, Z. Goodman, V. Wong, R. Loomba, F. Tacke, A. Sanyal, E. Lefebvre   +22 more
semanticscholar   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Randomized controlled trial of a smartphone app designed to reduce unhealthy alcohol consumption

Internet Interventions
Background and aims: Unhealthy alcohol use is common and causes tremendous harm. Most people with unhealthy alcohol use will never seek formal alcohol treatment.
John A. Cunningham, Alexandra Godinho, Christina Schell, Joseph Studer, Jeffrey D. Wardell, Claire Garnett, Nicolas Bertholet   +6 more
doaj   +1 more source

Mifepristone Antagonization With Progesterone to Prevent Medical Abortion: A Randomized Controlled Trial. [PDF]

, 2020
ObjectiveTo estimate the efficacy and safety of mifepristone antagonization with high-dose oral progesterone.MethodsWe planned to enroll 40 patients in a double-blind, placebo-controlled, randomized trial.
Chen, Melissa J, Creinin, Mitchell D, Dalton, Laura, Hou, Melody Y, Steward, Rachel   +4 more
core   +1 more source

Assessment of Long-term Follow-up of Randomized Trial Participants by Linkage to Routinely Collected Data: A Scoping Review and Analysis: A Scoping Review and Analysis [PDF]

, 2018
IMPORTANCE Follow-up of participants in randomized trials may be limited by logistic and financial factors. Some important randomized trials have been extended well beyond their original follow-up period by linkage of individual participant information ...
Cairncross, Zoe, Fitzpatrick, Tiffany, Henry, David, Lix, Lisa, Perrier, Laure, Rosella, Laura, Shakik, Sharara, Tricco, Andrea C, Zwarenstein, Merrick   +8 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Randomized controlled trial of Micro-Mobile Compression® on lactate clearance and subsequent exercise performance in elite male cyclists

Open Access Journal of Sports Medicine, 2013
Iñigo San Millán,1 Kristen Bing,1 Carrie Brill,1 John C Hill,1 Larry E Miller2 1University of Colorado School of Medicine, Aurora, CO, 2Miller Scientific Consulting, Inc, Arden, NC, USA Background: The purpose of this paper was to assess ...
San Millán I, Bing K, Brill C, Hill JC, Miller LE   +4 more
doaj  

Chemotherapy-induced peripheral neuropathy in cancer patients : a four-arm randomized trial on the effectiveness of electroacupuncture [PDF]

, 2013
Purpose. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting side effect of cytostatic drugs. Since there are no proven therapeutic procedures against CIPN, we were interested to define the role of electroacupuncture (EA) from
Bartsch, Hans Helge, Güthlin, Corina, Jaroslawski, Karin, Lüdtke, Rainer, Rostock, Matthias, Schröder, Sven   +5 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Do inhaled beta-agonists control cough in URIs or acute bronchitis? [PDF]

, 2004
Patients who receive inhaled beta-agonists for cough due to acute upper respiratory infections (URI) are just as likely to report a productive cough at 7 days compared with patients treated with placebo (strength of recommendation [SOR]: A, based on a ...
Nashelsky, Joan, Stephens, Mary Maniscalco   +1 more
core