Results 121 to 130 of about 43,824,661 (311)

Acceptance and Commitment Therapy group for treatment-resistant participants: a randomized controlled trial [PDF]

, 2014
Acceptance and Commitment Therapy (ACT) is a theoretically coherent approach addressing common processes across a range of disorders. The aim of this study was to investigate the effectiveness of a group-based ACT intervention for ‘treatment-resistant ...
Clarke, Sue, James, Kirsty, Remington, Bob, Remington, B., James, K., Kingston, Jessica, Kingston, J., Bolderston, Helen   +7 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Effect of statins on venous thromboembolic events: a meta-analysis of published and unpublished evidence from randomised controlled trials [PDF]

, 2012
Background - It has been suggested that statins substantially reduce the risk of venous thromboembolic events. We sought to test this hypothesis by performing a meta-analysis of both published and unpublished results from randomised trials of statins.
Jacquet Hervet, Michel, Pieter Kamphuisen, Wikstrand John, Bhala, Neeraj, Haluska, B. A., Sara Biere-Rafi (135090), Kostner, K., Emberson, J, Hegney, D., Pieter Kamphuisen (135078), Bolte, J., McMurray, J.J.V., Delhaas, T., Holliday, J., Wikstrand, J, Glasziou, P. P., Hall, A. S., Samani, N. J., Emberson, J., Carrington, M. J., Blankenberg, S., Reino Maceiras, Maria Victoria, Ling, H. L., Álvarez Álvarez, Belén, Alvarez Castro, Ezequiel, Michele Robertson (135100), Sara Biere-Rafi, Agra Bermejo, Rosa Maria, McMurray, John, Kazem Rahimi (135073), Kamphuisen, P., Frueh, M., Kamphuisen, Pieter, McMurray, J., Schute, F., McMurray John, Biere-Rafi, Sara, Reha-Sleep-Registry, Paradela Dobarro, Beatriz, García Acuña, José María, Janousek, J., Robertson, Michele, Wikstrand, John, Abuassi, Emad, Robertson, M., Kamphuisen, P, Kamke, W., Robertson Michele, Michele Robertson, Zeller, T., Biere-Rafi Sara, Stewart, S., McMurray, J, Peña Gil, Carlos, Rodiño Janeiro, Bruno K, Musameh, M. D., John McMurray, Wang, W. Y. S., Emberson Jonathan, S. Caravita, A. Faini, Neeraj Bhala (135075), John Wikstrand, John McMurray (135109), Keech, A. C., Vera Krane (135094), Jonathan Emberson, Van Geldorp, I., Jonathan Emberson (135084), Rahimi, Kazem, Tonkin, A. M., Elders, J., Rahimi, K, Schroeder, K., S. Salerno, Krane Vera, Krane, V, Vera Krane, Sullivan, D. R., Wikstrand, John,, Bhala, N., Prinzen, F. W., Nelson, C. P., E. Lisi, Krane, V., Biere-Rafi, S., Alt, B., Neeraj Bhala, Skobel, E., Grigorian Shamagian, Lilian, Ball, S. G., G. Parati, Biere-Rafi, S, Kazem Rahimi, ?, ?, Balmforth, A. J., Tomaszewski, M., M. Valentini, John Wikstrand (135105), White, H. D., Carrington, M., Schwaab, B., Rosenthal, E., Raposeiras Roubín, Sergio, Gestal Romani, Santiago, Bhala Neeraj, Cabanas Grandio, Maria Pilar, Emberson, Jonathan, Woehrle, H., Kamphuisen Pieter, Espinoza, D., Tomaske, M., Bhala, N, Hague, W., Rahimi Kazem, G. Bilo, Krane, Vera, P. Agostoni, Rahimi, K., Haluska, B., Krupickova, S., González Juanatey, José Ramón, González Cambeiro, María Cristina, Marwick, T. H., Wikstrand, J., Hiippala, A., Pereira Lopez, Eva Maria, Aguiar Souto, Pablo, Purucker, H. C., Boenner, G., Krüger, S., M. Revera, Simes, R. J., C. Lombardi, Robertson, M   +134 more
core   +2 more sources

Evaluating Age, Sex, Racial, and Ethnic Representation in Acute Ischemic Stroke Trials, 2010 to 2020: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Emily K. Acton, Mohammad Hossein Abbasi, Scott E. Kasner   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Randomized controlled trials in pediatric surgery: could we do better?

, 2003
BACKGROUND/PURPOSE: Randomized controlled trials (RCTs) are accepted as the gold standard for assessing the effectiveness of clinical interventions but are rarely reported in pediatric surgery. Have RCTs submitted to the British Association of Paediatric
Stringer, Mark D, Curry, Joe I, Reeves, Barnaby   +2 more
core   +1 more source

The Effect of Preoperative Magnetic Resonance Imaging on Long-term Oncological Outcomes Following Radical Prostatectomy—A 12-year Follow-up of a Randomized Controlled Trial

European Urology Open Science
Background and objective: The effect of preoperative magnetic resonance imaging (MRI) on long-term oncological outcomes following robot-assisted laparoscopic prostatectomy (RALP) is uncertain.
Daniyal Noor, Eduard Baco, Peter M. Lauritzen, Viktor Berge, Kristina F. Galtung, Maciej Jacewicz, Lars Magne Eri, Erik Rud   +7 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Optimizing soft tissue injury rehabilitation: PEACE & LOVE with vs without cryotherapy—protocol for a sham-controlled randomized trial in acute lateral ankle sprain

Trials
Background Acute lateral ankle sprains, especially those affecting the anterior talofibular ligament (ATFL), are one of the most frequent injuries in athletes and active adults.
Polok Halder, Md. Zahid Hossain, Md. Asfan Afroz Akash, Joy Saha, Md. Feroz Kabir, K. M. Amran Hossain, Sharmila Jahan, Kabir Hossain, Tofajjal Hossain, Ehsanur Rahman   +9 more
doaj   +1 more source

A Bayesian reevaluation of randomized controlled trials in assisted reproductive technology: quantifying evidence strength for null and alternative hypotheses

Frontiers in Endocrinology
IntroductionMany randomized controlled trials (RCTs) in assisted reproductive technology (ART) face widespread misinterpretation of statistically non-significant results within the conventional frequentist framework.
Jiayi Gao, Tian Tian, Kalbinur Kayimu, Yi Yuan, Yongyan Chen, Yu Fu, Rui Chen, Fang Liu, Yunjun Zhang, Yuanyuan Wang   +9 more
doaj   +1 more source