Randomized controlled trials as topic

Results 141 to 150 of about 57,506,680 (308)

Transcatheter aortic valve implantation versus surgical aortic valve replacement for treatment of severe aortic stenosis: comparison of results from randomized controlled trials and real-world data

Brazilian Journal of Cardiovascular Surgery
Objective: Results from randomized controlled trials (RCTs) and real-world study (RWS) appear to be discordant. We aimed to investigate whether data derived from RCTs and RWS evaluating long-term all-cause mortality of transcatheter aortic valve ...
Dandan Wang +7 more
doaj +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source

Effect size of COVID-19 mobility restrictions intensity on air pollution: a natural experiment

Scientific Reports
To improve air quality, regulatory actions targeting road traffic and industrial emissions must be implemented. This study determined the effect size (ES, Cohen’s δ) and the significance of progressive quarantine restrictions levels national quarantine ...
Aníbal A. Teherán +6 more
doaj +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source

A nationwide student survey on biochemistry learning resources in Italy

FEBS Open Bio, EarlyView.
We conducted a survey among Italian university students to investigate their preferred study materials for biochemistry. We then analyzed the collected data to identify these materials. This information may be valuable to the Biochemistry educational community. The graphical abstract was created with Claude (Opus 5.5; Anthropic, 2026).
Anna Marabotti +4 more
wiley +1 more source

Reporting quality of abstracts of randomized controlled trials published in leading orthodontic journals from 2006 to 2011

, 2012
Optimal reporting of randomized trials and abstracts enhances transparency and facilitates assessment and identification of trials. The purpose of this study was to investigate the quality of reporting of abstracts of randomized controlled trials ...
Seehra, Jadbinder +4 more
core +1 more source

Effectiveness of a physical literacy intervention program for young and middle-aged adults with hypertension: a mixed-methods quasi-experimental study

Frontiers in Endocrinology
ObjectiveTo examine whether a theoretically grounded, 8-week physical literacy intervention incorporating salutogenic model components (sense of coherence, social support, and self-efficacy) could improve physical activity levels and clinical outcomes in
Guiyue Ma, Guiyue Ma
doaj +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source

Characteristics of included randomized controlled trials.

, 2019
Characteristics of included randomized controlled trials.
Liwen Feng (6383711) +3 more
core +1 more source

Mapping of the evidence from systematic reviews of the Cochrane Collaboration for decision-making within physiotherapy

São Paulo Medical Journal
CONTEXT AND OBJECTIVEEvidence-based clinical practice emerged with the aim of guiding clinical issues in order to reduce the degree of uncertainty in decision-making.
Ane Helena Valle Versiani +2 more
doaj +1 more source

non-randomized controlled trials as topic
evidence-based medicine
systematic reviews as topic

research design