Results 231 to 240 of about 337,732 (285)

Update on Randomized Placebo-Controlled Trials in the Past Decade for Treatment of Major Depressive Disorder in Child and Adolescent Patients: A Systematic Review.

Journal of child and adolescent psychopharmacology, 2018
OBJECTIVES Antidepressant treatment for major depressive disorder (MDD) has been a topic of continued interest with a number of placebo randomized-controlled trials (RCTs) being published in the past decade.
M. Ignaszewski, B. Waslick
semanticscholar   +1 more source

Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials

Clinical Rheumatology, 2015
The objective of this study was to evaluate the efficacy and safety of topical diclofenac therapy for osteoarthritis (OA). A meta-analysis of randomized controlled trials was conducted. A comprehensive literature search, covering the databases of Medline, the Cochrane Central Register of Controlled Trials, and EMBASE, was conducted in September 2014 to
Zhen-han Deng, Chao Zeng, Ye Yang, Yu-sheng Li, Jie Wei, Tuo Yang, Hui Li, Guang-hua Lei   +7 more
openaire   +2 more sources

Topical Anesthetics for Dermal Instrumentation: A Systematic Review of Randomized, Controlled Trials

Annals of Emergency Medicine, 2005
We compare the analgesic efficacy of topical anesthetics for dermal instrumentation with conventional infiltrated local anesthesia and also compare topically available amide and ester agents with a eutectic mixture of local anesthetics (EMLA).We conducted a systematic review of randomized, controlled trials.
Anthony, Eidelman, Jocelyn M, Weiss, Joseph, Lau, Daniel B, Carr   +3 more
openaire   +2 more sources

Topical Analgesia for Endometrial Biopsy

Obstetrics & Gynecology, 2005
To estimate whether benzocaine spray applied to the cervix and the endocervical canal before performing office endometrial biopsy improves patient comfort during the procedure.Eighty-eight women were randomly assigned to receive either 20% benzocaine spray or placebo to the outside of the cervix and into the endocervical canal before an endometrial ...
Jon I, Einarsson, Gwendolyn, Henao, Amy E, Young   +2 more
openaire   +2 more sources

Effects of Topical Antifibrinolytics in Endoscopic Sinus Surgery: A Pilot Randomized Controlled Trial

American Journal of Rhinology, 2007
Background Bleeding in endoscopic sinus surgery (ESS) may increase the risk of intraoperative complications and is associated with poorer outcomes Antifibrinolytic agents have been shown to reduce bleeding if administered systemically. The aim of this study was to determine the effect of topical epsilon-aminocaproic acid (EACA) and tranexamic acid (TA)
Athanasiadis, T., Beule, A., Wormald, P.
openaire   +3 more sources

Effect of topical diclofenac on postoperative photorefractive keratectomy pain: a randomized, controlled trial

Clinical & Experimental Ophthalmology, 2014
AbstractBackgroundA major disadvantage of photorefractive keratectomy is postoperative pain and discomfort. This study aims to evaluate whether topical diclofenac 0.1% therapy adds any extra benefit to systemic diclofenac in controlling pain after photorefractive keratectomy.DesignProspective randomized, double‐masked clinical trial applied in the ...
Alireza, Eslampoor, Asieh, Ehsaei, Mojtaba, Abrishami   +2 more
openaire   +2 more sources

Topical Sucralfate Treatment of Anal Fistulotomy Wounds: A Randomized Placebo-Controlled Trial

Diseases of the Colon & Rectum, 2011
Sucralfate is a cytoprotective agent which adheres to mucoproteins and forms a protective barrier at wound sites. In oral form it is a common ulcer medication, and as a topical preparation it has been used to treat a wide variety of wounds.The present study was designed to evaluate the effectiveness and safety of topical sucralfate in wound healing ...
Pravin J, Gupta, Purushottam S, Heda, Subhash A, Shrirao, Surekha S, Kalaskar   +3 more
openaire   +2 more sources

A RANDOMIZED CONTROLLED TRIAL OF INTRACAMERAL LIDOCAINE DURING PHACOEMULSIFICATION UNDER TOPICAL ANESTHESIA

Evidence-Based Eye Care, 2000
To test the hypothesis that adjunctive intracameral 1% lidocaine reduces intraoperative pain during phacoemulsification using topical anesthesia.Prospective, double-masked, randomized, controlled trial.A total of 200 patients undergoing routine phacoemulsification under topical 1% tetracaine were studied.Randomization to 0.5 ml intracameral ...
J E, Boulton, A, Lopatatzidis, J, Luck, R M, Baer   +3 more
openaire   +2 more sources

Topical Anesthesia in Cutaneous Head and Neck Surgery: A Randomized Controlled Trial

Otolaryngology–Head and Neck Surgery
AbstractObjectiveCutaneous head and neck surgery can safely and effectively be performed using local anesthetic (LA). However, optimizing pain management during LA administration is paramount for patient comfort and procedural efficacy. The primary objective of this study was to investigate the comparative effectiveness of EMLA cream and ethyl chloride
Rory, O'Neill, Adrinda, Affendi, Nathaniel, McHugh, Liam, Skinner   +3 more
openaire   +2 more sources

Randomized Controlled Trial of Topical Hyperbaric Oxygen for Treatment of Diabetic Foot Ulcers

Diabetes Care, 1988
The effect of 2 wk of topical hyperbaric oxygen (THO) treatment on the healing of diabetic foot ulcers without associated gangrene was evaluated in a prospective, controlled, and randomized manner in 28 patients. There were 12 patients in the THO group (group 1) and 16 in the control group (group 2).
C A, Leslie, F L, Sapico, V J, Ginunas, R H, Adkins   +3 more
openaire   +2 more sources