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A Randomized Vehicle-Controlled Trial of Topical Capsaicin in the Treatment of Postherpetic Neuralgia

Survey of Anesthesiology, 1994
A large double-blind, vehicle-controlled study of 143 patients with chronic postherpetic neuralgia (PHN) was performed to evaluate the degree of efficacy of topically applied capsaicin 0.075% cream. In addition, the safety and efficacy of long-term application of topical capsaicin in PHN was assessed by following patients in an open-label study for up ...
C. Peter N. Watson   +5 more
openaire   +3 more sources

Topical diclofenac therapy for osteoarthritis: a meta-analysis of randomized controlled trials

Clinical Rheumatology, 2015
The objective of this study was to evaluate the efficacy and safety of topical diclofenac therapy for osteoarthritis (OA). A meta-analysis of randomized controlled trials was conducted. A comprehensive literature search, covering the databases of Medline, the Cochrane Central Register of Controlled Trials, and EMBASE, was conducted in September 2014 to
Zhen-han Deng   +7 more
openaire   +3 more sources

Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial

British Journal of Dermatology, 2006
The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator-blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish-and-spit medication for 5 min three times daily) or a corticosteroid oral paste (triamcinolone
H. von Domarus   +4 more
openaire   +2 more sources

Topical Anesthetics for Dermal Instrumentation: A Systematic Review of Randomized, Controlled Trials

Annals of Emergency Medicine, 2005
We compare the analgesic efficacy of topical anesthetics for dermal instrumentation with conventional infiltrated local anesthesia and also compare topically available amide and ester agents with a eutectic mixture of local anesthetics (EMLA).We conducted a systematic review of randomized, controlled trials.
Jocelyn M. Weiss   +3 more
openaire   +3 more sources

Acute appendicitis can be treated with single‐incision laparoscopy: a systematic review of randomized controlled trials

Colorectal Disease, 2015
Single‐incision laparoscopic surgery (SILS) has been proposed as the next step in minimally invasive surgery for appendicectomy. Previous reviews have summarized the results of low‐evidence comparative studies, suggesting that the two approaches are ...
N. Vettoretto   +3 more
semanticscholar   +1 more source

The Quality of Randomized Controlled Trials in Pediatric Orthopaedics: Are We Improving?

Journal of pediatric orthopedics, 2015
Purpose: The quality of randomized controlled trials (RCTs) in orthopaedics is a topic of considerable importance, as RCTs play a major role in guiding clinical practice. The quality of RCTs published between 1995 and 2005 has previously been documented.
E. Dodwell   +4 more
semanticscholar   +1 more source

Topical Tranexamic Acid in Breast Reconstruction: A Double-Blind, Randomized Controlled Trial

Plastic & Reconstructive Surgery, 2023
BACKGROUND Excess fluid accumulation (seroma/hematoma) around the breast implant post reconstruction can lead to significant complications. Topical administration of tranexamic acid (TXA) may reduce fluid accumulation and reduce post-operative complications.
Tyler, Safran   +4 more
openaire   +2 more sources

The Efficacy and Safety of Prone Positional Ventilation in Acute Respiratory Distress Syndrome: Updated Study-Level Meta-Analysis of 11 Randomized Controlled Trials*

Critical Care Medicine, 2014
Objective:The survival benefit of prone positioning during mechanical ventilation for acute respiratory distress syndrome has been a matter of debate. Recent multicenter randomized controlled trials have shown a significant reduction of 28-day and 90-day
J. Lee, Won Bae, Y. Lee, Y. Cho
semanticscholar   +1 more source

A randomized controlled trial of R-salbutamol for topical treatment of discoid lupus erythematosus

British Journal of Dermatology, 2009
In a recent open pilot trial, R-salbutamol sulphate, a well-known molecule with anti-inflammatory effects, was tested successfully on patients with therapy-resistant discoid lupus erythematosus (DLE).To compare the efficacy and safety of R-salbutamol cream 0.5% vs.
Jemec, G B E   +11 more
openaire   +5 more sources

A Randomized Controlled Trial of Topical Cannabidiol for the Treatment of Thumb Basal Joint Arthritis

The Journal of Hand Surgery, 2022
Since the passage of the Agricultural Improvement Act of 2018, hand surgeons have increasingly encountered patients seeking counseling on over-the-counter, topical cannabidiol (CBD) for the treatment of pain. To this end, we designed a human clinical trial to investigate the therapeutic potential of CBD for the treatment of pain associated with thumb ...
John T, Heineman   +5 more
openaire   +2 more sources

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