Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Comment on "Recreational Athletes' Use of Performance‑Enhancing Substances: Results from the First European Randomized Response Technique Survey". [PDF]
Sports Med Open, 2023 Petrou M, Lazuras L.
europepmc +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Authors' Reply to Petrou & Lazuras: 'Recreational Athletes' Use of Performance-Enhancing Substances: Results from the First European Randomized Response Technique Survey'. [PDF]
Sports Med Open, 2023 Christiansen AV +3 more
europepmc +1 more source
Randomized Dimension Reduction on Massive Data [PDF]
, 2013 Scalability of statistical estimators is of increasing importance in modern applications and dimension reduction is often used to extract relevant information from data.
Georgiev, Stoyan, Mukherjee, Sayan
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Anonymity and incentives: An investigation of techniques to reduce socially desirable responding in the Trust Game [PDF]
Judgment and Decision Making, 2016 Economic games offer a convenient approach for the study of prosocial behavior. As an advantage, they allow for straightforward implementation of different techniques to reduce socially desirable responding.
Isabel Thielmann +2 more
doaj
Recreational Athletes' Use of Performance-Enhancing Substances: Results from the First European Randomized Response Technique Survey. [PDF]
Sports Med Open, 2023 Christiansen AV +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Sample Size Determination for Interval Estimation of the Prevalence of a Sensitive Attribute Under Randomized Response Models. [PDF]
Psychometrika, 2022 Qiu SF, Tang ML, Tao JR, Wong RS.
europepmc +1 more source