Results 201 to 210 of about 10,550,867 (315)

Plasma 5-Fluorouracil Exposure, Clinical Outcomes, and Therapeutic Drug Monitoring in Advanced Colorectal Cancer. [PDF]

Cancers (Basel)
Sakuyama N, Nagayasu K, Abe Y, Ochiai T, Shibasaki F.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Is a combined proximal femoral osteotomy necessary when performing open reduction and Dega acetabuloplasty in walking-age children with developmental dysplasia of the hip. [PDF]

SICOT J
Yu J, Li L, Shi L, Zhang L, Li Q, Wang E.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Multiscale reorganisation of colloidal aggregation by percolating bacterial networks.

Soft Matter
Stricker L, Charlton SGV, Secchi E.
europepmc   +1 more source

Distribution, Habitat Use and Conservation of the Bornean Ferret Badger. [PDF]

Ecol Evol
Hearn AJ, Jaini MAB, Sartor CC, Salam PMSB, Martin A, Gomez C, Macdonald DW.   +6 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Real-world experience with tabelecleucel within and beyond the approval label. [PDF]

Blood Adv
Farid KMN, Kocher F, Arnold T, Fauser J, Henze E, Schultze-Florey C, Herling CD, Vučinić V, Reicherts C, Stelljes M, Stadelmann R, Scheid C, Holtick U, Masouridi-Levrat S, Wehrli M, Novak U, Schnitzler P, Ben-Salah C, Krämer I, Schmitt A, Müller-Tidow C, Luft T, Dreger P, Schmitt M.   +23 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Five-year outcomes of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) in adults with type 1 diabetes mellitus. [PDF]

Endocrine
Rao RS, Hogan G, Rao A, Sweeny A, Mehta M.   +4 more
europepmc   +1 more source