Results 81 to 90 of about 37,814 (299)

Indication‐Specific Dosing and Dose‐Evaluation Strategies in New Indications for Non‐Oncology Monoclonal Antibodies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley   +1 more source

Outcomes and risk factors associated with endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. [PDF]

, 2011
OBJECTIVE: To describe outcomes of and risk factors for endophthalmitis after intravitreal anti-vascular endothelial growth factor (VEGF) injection. DESIGN: Single-center, consecutive, case series and retrospective case-control study.
Brown, Gary C, Garg, Sunir J, Haller, Julia A, Kaiser, Richard S, Shah, Chirag P, The Post-Injection Endophthalmitis (PIE) Study Team,, Vander, James F   +6 more
core   +2 more sources

Cost-effectiveness Analysis of Ranibizumab Biosimilar for Neovascular Age-Related Macular Degeneration and its Subtypes from the Societal and Patient Perspectives in Japan

Ophthalmology and Therapy
Introduction This study evaluated the cost-effectiveness of anti-vascular endothelial growth factor (VEGF) therapies for subtypes of neovascular age-related macular degeneration (nAMD) from the societal perspective, and for any nAMD from the patient ...
Yasuo Yanagi, Kanji Takahashi, Tomohiro Iida, Fumi Gomi, Hiroshi Onishi, Junko Morii, Taiji Sakamoto   +6 more
doaj   +1 more source

Comparison between intravitreal ranibizumab injection and posterior subtenon triamcinolone acetonide injection at time of cataract surgery for prevention of progression of diabetic macular edema

BMC Ophthalmology, 2022
Background The goal of this work is to assess progression of diabetic macular edema (DME) following intravitreal ranibizumab injection compared to subtenon triamcinolone acetonide injection at cataract operation. Methods Retrospective analysis of 73 eyes
Mahmoud Mohammed Ahmed Ali Khalil, Hosam Othman Mansour, Ahmed Mohamed Raafat Tawfik, Ahmed Gomaa Elmahdy   +3 more
doaj   +1 more source

The Application of Structural Retinal Biomarkers to Evaluate the Effect of Intravitreal Ranibizumab and Dexamethasone Intravitreal Implant on Treatment of Diabetic Macular Edema

Diagnostics, 2020
Background: The aim of this study was to compare the therapeutic effect of intravitreal treatment with ranibizumab and dexamethasone using specific swept-source optical coherence tomography retinal biomarkers in patients with diabetic macular edema (DME).
I. Ceravolo, G. Oliverio, A. Alibrandi, A. Bhatti, Luigi Trombetta, R. Rejdak, M. Toro, C. Trombetta   +7 more
semanticscholar   +1 more source

Evaluation of the Response to Ranibizumab Therapy following Bevacizumab Treatment Failure in Eyes with Diabetic Macular Edema

Case Reports in Ophthalmology, 2015
Background/Aims: Bevacizumab and ranibizumab are routinely used to treat diabetic macular edema (DME). We aim to evaluate the usefulness of switching to ranibizumab therapy following bevacizumab treatment failure in eyes with DME. Methods: We performed a
Joel Hanhart, Itay Chowers
doaj   +1 more source

Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2015
IMPORTANCE Panretinal photocoagulation (PRP) is the standard treatment for reducing severe visual loss from proliferative diabetic retinopathy. However, PRP can damage the retina, resulting in peripheral vision loss or worsening diabetic macular edema ...
J. Gross, A. Glassman, L. Jampol, S. Inusah, L. Aiello, A. Antoszyk, C. Baker, B. Berger, N. Bressler, D. Browning, M. Elman, F. Ferris, S. Friedman, D. Marcus, M. Melia, Cynthia R. Stockdale, Jennifer K. Sun, R. Beck   +17 more
semanticscholar   +1 more source

Current Advances in the Combination of Fatty Acids and Resveratrol to Fight Ocular Diseases

Molecular Nutrition &Food Research, EarlyView.
Graphical abstract illustrating the effects of Resvega administration on choroidal neovascularization and resveratrol metabolism in the retina. The diagram illustrates that oral administration of Resvega leads to a decrease in choroidal neovascularization.
Dominique Delmas, Maude Perus, Virginie Aires, François Hermetet   +3 more
wiley   +1 more source

Anti-vascular endothelial growth factor for neovascular age-related macular degeneration: a meta-analysis of randomized controlled trials

BMC Ophthalmology, 2018
Background To evaluate the relative efficacy and safety of anti-vascular endothelial growth factor (anti-VEGF) agents for the treatment of neovascular age-related macular degeneration (AMD). Methods Systematic literature review identifying RCTs comparing
Chu Luan Nguyen, Lawrence J. Oh, Eugene Wong, Joe Wei, Michael Chilov   +4 more
doaj   +1 more source

Efficacy and Safety of a Proposed Ranibizumab Biosimilar Product vs a Reference Ranibizumab Product for Patients With Neovascular Age-Related Macular Degeneration

JAMA ophthalmology, 2020
Key Points Question Does SB11, a proposed ranibizumab biosimilar product, have equivalent best-corrected visual acuity (BCVA) and optical coherence tomography central subfield thickness (CST) outcomes and a similar safety profile to the reference ...
S. Woo, M. Veith, J. Hamouz, J. Ernest, D. Zalewski, J. Studnicka, A. Vajas, A. Papp, Vogt Gabor, J. Luu, V. Matušková, Y. Yoon, T. Pregun, Taehyung Kim, Donghoon Shin, N. Bressler   +15 more
semanticscholar   +1 more source