Results 91 to 100 of about 464,627 (312)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Hierarchically hyperbolic spaces I: curve complexes for cubical groups [PDF]
, 2016 In the context of CAT(0) cubical groups, we develop an analogue of the theory of curve complexes and subsurface projections. The role of the subsurfaces is played by a collection of convex subcomplexes called a \emph{factor system}, and the role of the ...
Agol +9 more
core +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
When Does an Ensemble of Matrices with Randomly Scaled Rows Lose Rank?
, 2015 We consider the problem of determining rank loss conditions for a concatenation of full-rank matrices, such that each row of the composing matrices is scaled by a random coefficient.
Avestimehr, A. Salman +2 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Fast Searching Strategy for Critical Cascading Paths Toward Blackouts
IEEE Access, 2018 The analysis of severe cascading blackouts is an essential issue in power grid planning and operation. As there are a tremendous number of possible cascade paths in a large power system, it is very challenging to determine the critical cascading paths ...
Zhiyuan Ma +4 more
doaj +1 more source
TEST CASE PRIORITIZATION USING HYPERLINK RANKING - A GRAPH THEORY BASED APPROACH
International Journal of Research in Engineering and Technology, 2013 Era of cloud computing where majority of the applic ation is becoming web based enterprise computing. U ser prefer online web application for easy of use and business continuity [1]. Software companies have come up in huge numbe rs for developing web based enterprise application.
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
When do correlations increase with firing rates in recurrent networks? [PDF]
PLoS Computational Biology, 2017 A central question in neuroscience is to understand how noisy firing patterns are used to transmit information. Because neural spiking is noisy, spiking patterns are often quantified via pairwise correlations, or the probability that two cells will spike
Andrea K Barreiro, Cheng Ly
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source