Results 91 to 100 of about 468,741 (299)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Flip-Breakability: A Combinatorial Dichotomy for Monadically Dependent Graph Classes [PDF]

Symposium on the Theory of Computing
A conjecture in algorithmic model theory predicts that the model-checking problem for first-order logic is fixed-parameter tractable on a hereditary graph class if and only if the class is monadically dependent.
Jan Dreier, Nikolas Mählmann, Szymon Toruńczyk   +2 more
semanticscholar   +1 more source

Constructing and Classifying Fully Irreducible Outer Automorphisms of Free Groups

, 2012
The main theorem of this document emulates, in the context of Out(F_r) theory, a mapping class group theorem (by H. Masur and J. Smillie) that determines precisely which index lists arise from pseudo-Anosov mapping classes.
Pfaff, Catherine
core   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

An arbitrary segmentation method for loss allocation in power grids with distributed generation

International Journal of Electrical Power & Energy Systems
The issue of network loss allocation is crucial for the economic operation of power grids, as fair distribution ensures that participants allocate the cost of losses in proportion to their actual contributions.
Wenqiang Tao, Hongkun Chen, Lei Chen, Shengbin Chen   +3 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

C*-algebras of higher-rank graphs from groups acting on buildings, and explicit computation of their K-theory [PDF]

, 2020
Sam A. Mutter, Aura-Cristiana Radu, Alina Vdovina   +2 more
openalex   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

The K-theory of the C*-algebras of 2-rank graphs associated to complete bipartite graphs [PDF]

, 2020
Sam A. Mutter
openalex   +1 more source