Results 91 to 100 of about 457,473 (310)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Fast Searching Strategy for Critical Cascading Paths Toward Blackouts

IEEE Access, 2018
The analysis of severe cascading blackouts is an essential issue in power grid planning and operation. As there are a tremendous number of possible cascade paths in a large power system, it is very challenging to determine the critical cascading paths ...
Zhiyuan Ma, Feng Liu, Chen Shen, Zhaojian Wang, Shengwei Mei   +4 more
doaj   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

When do correlations increase with firing rates in recurrent networks? [PDF]

PLoS Computational Biology, 2017
A central question in neuroscience is to understand how noisy firing patterns are used to transmit information. Because neural spiking is noisy, spiking patterns are often quantified via pairwise correlations, or the probability that two cells will spike
Andrea K Barreiro, Cheng Ly
doaj   +1 more source

When Does an Ensemble of Matrices with Randomly Scaled Rows Lose Rank?

, 2015
We consider the problem of determining rank loss conditions for a concatenation of full-rank matrices, such that each row of the composing matrices is scaled by a random coefficient.
Avestimehr, A. Salman, Gamal, Aly El, Naderializadeh, Navid   +2 more
core   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Rank-Based Comparative Research Flow Benchmarking the Effectiveness of AHP–GTMA on Aiding Decisions of Shredder Selection by Reference to AHP–TOPSIS

Applied Sciences, 2018
The AHP–GTMA (analytic hierarchy process and graph theory and matrix approach) has been applied to select the best paper shredder before a company was making a bulk purchase order.
Zheng-Yun Zhuang, Chang-Ching Lin, Chih-Yung Chen, Chia-Rong Su   +3 more
doaj   +1 more source

The method of increasing the efficiency of the man-machine system functioning by improving the quality of decision support system software

Наука і техніка Повітряних Сил Збройних Сил України, 2020
The article addresses improving the performance of man-machine systems (MMS) by improving the quality of decision support system software (DSSS). The proposed solutions are based on existing models and methods, which have been analysed in detail in a ...
О.В. Турінський, М.А. Павленко, Г.В. Пєвцов, С.В. Осієвський   +3 more
doaj   +1 more source

Some approximate fixed point results and application on graph theory for partial (h-F)-generalized convex contraction mappings with special class of functions on complete metric space

, 2017
In this paper, we introduce a new concept called partial (h-F)-generalized (and (h-F)-subgeneralized) convex contractions of order 3 (and with rank 3) using some auxiliary functions.
M. Jaradat, Z. Mustafa, A. H. Ansari, S. Chandok, C. Dolicanin   +4 more
semanticscholar   +1 more source