Results 91 to 100 of about 332,227 (273)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Rank-Based Comparative Research Flow Benchmarking the Effectiveness of AHP–GTMA on Aiding Decisions of Shredder Selection by Reference to AHP–TOPSIS

Applied Sciences, 2018
The AHP–GTMA (analytic hierarchy process and graph theory and matrix approach) has been applied to select the best paper shredder before a company was making a bulk purchase order.
Zheng-Yun Zhuang, Chang-Ching Lin, Chih-Yung Chen, Chia-Rong Su   +3 more
doaj   +1 more source

The method of increasing the efficiency of the man-machine system functioning by improving the quality of decision support system software

Наука і техніка Повітряних Сил Збройних Сил України, 2020
The article addresses improving the performance of man-machine systems (MMS) by improving the quality of decision support system software (DSSS). The proposed solutions are based on existing models and methods, which have been analysed in detail in a ...
О.В. Турінський, М.А. Павленко, Г.В. Пєвцов, С.В. Осієвський   +3 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The Maximum Order of Reduced Square(0, 1)-Matrices with a Given Rank [PDF]

We look for the maximum order of a square (0, 1)-matrix A with a fixed rank r, provided A has no repeated rows or columns. If A is the adjacency matrix of a graph, Kotlov and Lovász [J. Graph Theory 23, 1996] proved that the maximum order equals Θ(2r/2).
Haemers, W.H., Peeters, M.J.P.
core   +1 more source

Constructing and Classifying Fully Irreducible Outer Automorphisms of Free Groups

, 2012
The main theorem of this document emulates, in the context of Out(F_r) theory, a mapping class group theorem (by H. Masur and J. Smillie) that determines precisely which index lists arise from pseudo-Anosov mapping classes.
Pfaff, Catherine
core   +1 more source

$C^{\star}$-algebras of higher-rank graphs from groups acting on buildings, and explicit computation of their K-theory

Publicacions Matemàtiques
We unite elements of category theory, K-theory, and geometric group theory, by defining a class of groups called $k$-cube groups, which act freely and transitively on the product of $k$ trees, for arbitrary $k$. The quotient of this action on the product of trees defines a $k$-dimensional cube complex, which induces a higher-rank graph.
Sam A. Mutter, Aura-Cristiana Radu, Alina Vdovina   +2 more
openaire   +4 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

An arbitrary segmentation method for loss allocation in power grids with distributed generation

International Journal of Electrical Power & Energy Systems
The issue of network loss allocation is crucial for the economic operation of power grids, as fair distribution ensures that participants allocate the cost of losses in proportion to their actual contributions.
Wenqiang Tao, Hongkun Chen, Lei Chen, Shengbin Chen   +3 more
doaj   +1 more source