Results 91 to 100 of about 1,465,496 (351)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Modeling Multivariate Distributions with Continuous Margins Using the copula R Package
Journal of Statistical Software, 2010 The copula-based modeling of multivariate distributions with continuous margins is presented as a succession of rank-based tests: a multivariate test of randomness followed by a test of mutual independence and a series of goodness-of-fit tests.
Ivan Kojadinovic, Jun Yan
doaj
Local and global rank tests for multivariate varying-coefficient models [PDF]
In a multivariate varying-coefficient model, the response vectors Y are regressed on known functions u(X) of some explanatory variables X and the coefficients in an unknown regression matrix q(Z) depend on another set of explanatory variables Z.
Natércia Fortuna +2 more
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Statistical Tests of the Rank of a Matrix and Their Applications in Econometric Modelling [PDF]
Testing the rank of a matrix of estimated parameters is key in a large variety of econometric modelling scenarios. This paper describes general methods to test for the rank of a matrix, and provides details on a variety of modelling scenarios in the ...
George Kapetanios, Gonzalo Camba-Mendez
core
Biometrical Journal, 2002 An exact rank test for two dependent samples based on overall mid-ranks is discussed which can be applied to metric as well as to ordinal data. The exact conditional distribution of the test statistic given the observed vector of rank differences is determined. A recursion formula is given as well as a fast shift algorithm in SAS/IML code. Moreover, it
Munzel, U., Brunner, E.
openaire +2 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Smoothed nonparametric two-sample tests
, 2017 We propose new smoothed median and the Wilcoxon's rank sum test. As is pointed out by Maesono et al.(2016), some nonparametric discrete tests have a problem with their significance probability. Because of this problem, the selection of the median and the
Maesono, Yoshihiko, Moriyama, Taku
core +1 more source