Results 211 to 220 of about 1,465,496 (351)

On Window Mean Survival Time With Interval-Censored Data. [PDF]

Stat Med
Iijima T, Momozaki T, Ando S.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses. [PDF]

Nat Commun
Bai M, Yin T, Li X, Wang P, Lei T, Jin P, Li F, Guo H, Guo X, Sun X, Li Y, Zou B, Yu J, Liu C, Teng F.   +14 more
europepmc   +1 more source

Rank tests invariant only under linear transformations

, 1969
Robert L. Obenchain
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Respiratory Muscle Strength and Imaging Parameters in Smokers: A Prospective Observational Study. [PDF]

Int J Chron Obstruct Pulmon Dis
Matsuo Y, Ogawa E, Iriyama T, Tsunoda Y, Yamazaki A, Uchida Y, Nakagawa H, Kinose D, Yamaguchi M, Nakano Y.   +9 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Bisphosphonate and statin: adverse effects of co-medication on wound healing in in vitro models of periodontal tissues. [PDF]

Acta Odontol Scand
Småland-Reksten A, Agger AE, Lian AM, Reseland JE, Krüger TB.   +4 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Developing and validating a machine learning model for predicting post-thrombolysis seizures in acute ischemic stroke. [PDF]

Medicine (Baltimore)
Jia L, Hu Y, Jin G, Zhou Z.
europepmc   +1 more source