Results 221 to 230 of about 16,829,601 (344)

Estimating Regression Parameters Using Linear Rank Tests for Censored Data

, 1990
A. Tsiatis
semanticscholar   +1 more source

Dynamics of oscillatory power support the integration of perceptual and mnemonic information within the premotor cortex. [PDF]

Nat Commun
Marc IB, Giuffrida V, Ramawat S, Bardella G, Ferraina S, Brunamonti E.   +5 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence. [PDF]

Elife
Hashikawa K, Hashikawa Y, Briones B, Ishii KK, Liu Y, Rossi M, Basiri ML, Chen JY, Ahmad O, Mukundan R, Johnston N, Simon R, Soetedjo J, Siputro J, McHenry J, Palmiter RD, Rubinow D, Zweifel LS, Stuber GD.   +18 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Efficient Calculation of Jackknife Confidence Intervals for Rank Statistics

An algorithm is presented for calculating concordance-discordance totals in a time of order N log N , where N is the number of observations, using a balanced binary search tree.
Roger Newson
core  

An eye-tracking-based Stroop test: an efficient method for evaluating frontal lobe function. [PDF]

Front Aging Neurosci
Yamamoto S, Takeda S, Miki S, Teshirogi S, Kishino Y, Katsuhisa M, Okawara M, Oyama A, Ito Y, Nakajima T, Takami Y, Takeya Y, Yamamoto K, Morishita R.   +13 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Rank tests for the observability of discrete-time jump linear systems with inputs

American Control Conference, 2009
Ehsan Elhamifar, M. Petreczky, R. Vidal
semanticscholar   +1 more source

Effects of the novel phosphodiesterase 9 inhibitor irsenontrine on CSF proteomics profile in Aβ⁺ and Aβ^- dementia with Lewy bodies patients. [PDF]

Alzheimers Res Ther
Oosthoek M, In 't Veld SGJG, Vermunt L, Ye Y, van Ingen M, Koel-Simmelink M, Vijverberg EGB, Saxena S, Hersch S, Irizarry M, Sachdev P, Teunissen CE.   +11 more
europepmc   +1 more source