Results 231 to 240 of about 90,467 (297)

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

TransPilot: mining key transcription factors by correlating binding sites with differentially expressed genes. [PDF]

Bioinform Adv
Tinghua H, Min Y, Fanghong Z, Siqi N, Jingchun W, Jianwu W, Ye Y, Xuejun G.   +7 more
europepmc   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Absolute Binding Free Energy Calculations between the SARS-CoV-2 Main Protease and 130 Drug Leads Using Implicit Ligand Theory. [PDF]

J Chem Inf Model
Nguyen HH, Xie B, Minh DDL.
europepmc   +1 more source

AI-Based Predictive Maintenance Framework for Industrial Saw Blade Wear Monitoring Using Low-Cost Vibration Sensors. [PDF]

Sensors (Basel)
Alfaris H, Daoud O, Kneifel J, Suyyagh A.   +3 more
europepmc   +1 more source

Structural optimization of drug molecules with incrementally trained language models. [PDF]

Nat Commun
Hörmann T, Mayer D, Lewandowski M, Hunklinger A, Wein T, Merk D.   +5 more
europepmc   +1 more source

MolFoundry: A Structure-Aware Generative Framework for De Novo Design of PRRSV Nucleocapsid Candidate Binders. [PDF]

ACS Omega
Hao J, Jin W.
europepmc   +1 more source

First-Trimester Gestational Diabetes Mellitus Risk Prediction with Machine Learning Techniques: Results from the BORN2020 Cohort Study. [PDF]

J Clin Med
Pazaras N, Siargkas A, Tranidou A, Apostolopoulou A, Tsakiridis I, Bamidis PD, Stavros S, Potiris A, Chourdakis M, Dagklis T.   +9 more
europepmc   +1 more source

Chlorophyll-a Retrieval in Turbid Inland Waters Using BC-1A Multispectral Observations: A Case Study of Taihu Lake. [PDF]

Sensors (Basel)
Jiang W, Guo Q, Cao C, Liu S.
europepmc   +1 more source

Ranked Set Sampling for Replicated Sampling Designs

Biometrics, 2002
In practical ecological sampling studies, a certain design (such as plot sampling or line-intercept sampling) is usually replicated more than once. For each replication, the Horvitz-Thompson estimation of the objective parameter is considered. Finally, an overall estimator is achieved by averaging the single Horvitz-Thompson estimators.
Barabesi, Lucio, Pisani, Caterina
openaire   +5 more sources