Results 101 to 110 of about 12,421,662 (339)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Rank metric codes and zeta functions [PDF]
Designs, Codes and Cryptography, 2017 We define the rank-metric zeta function of a code as a generating function of its normalized $q$-binomial moments. We show that, as in the Hamming case, the zeta function gives a generating function for the weight enumerators of rank-metric codes. We further prove a functional equation and derive an upper bound for the minimum distance in terms of the ...
Iván Blanco-Chacón +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Croatian Operational Research Review, 2017 The paper discusses the problem of ranking research projects based on the assessment obtained from n ≥ 1 independent blinded reviewers. Each reviewer assesses several project features, and the total score is defined as the weighted arithmetic mean, where
Rudolf Scitovski +3 more
doaj +1 more source
Protein–ligand scoring functions are widely used in structure-based drug design for fast evaluation of protein–ligand interactions, and it is of strong interest to develop scoring functions with machine-learning approaches. In this work, by expanding the
Chao Yang (174810) +1 more
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
, 1999 The paper first points out that ranking functions are superior to AGM belief revision theory in two crucial respects, i.e. in solving the problem of iterated belief revision and in giving an adequate account of doxastic independence (this was indeed why ...
Spohn, Wolfgang
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Synthesis of Linear Ranking Functions [PDF]
, 2001 Deductive verification of progress properties relies on finding ranking functions to prove termination of program cycles. We present an algorithm to synthesize linear ranking functions that can establish such termination. Fundamental to our approach is the representation of systems of linear inequalities and sets of linear expressions as polyhedral ...
Michael Colón, Henny Sipma
openaire +1 more source